Seroatlas · Human Serome Atlas

SFXN2

Sideroflexin-2

Also known as: SFXN2_HUMAN, SLC56A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NB2
Gene: SFXN2
Ensembl: ENSG00000156398
Chromosome: 10
Canonical length: 322 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Involved in mitochondrial transmembrane transport. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q96NB2|SFXN2
     1  MEADLSGFNI DAPRWDQRTF LGRVKHFLNI TDPRTVFVSE RELDWAKVMV EKSRMGVVPP
    61  GTQVEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQLPGGM IITGFMLQFY RTMPAVIFWQ
   121  WVNQSFNALV NYTNRNAASP TSVRQMALSY FTATTTAVAT AVGMNMLTKK APPLVGRWVP
   181  FAAVAAANCV NIPMMRQQEL IKGICVKDRN ENEIGHSRRA AAIGITQVVI SRITMSAPGM
   241  ILLPVIMERL EKLHFMQKVK VLHAPLQVML SGCFLIFMVP VACGLFPQKC ELPVSYLEPK
   301  LQDTIKAKYG ELEPYVYFNK GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFXN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

kidney: 17 nTPM
parathyroid gland: 12 nTPM
salivary gland: 4.6 nTPM
liver: 3.9 nTPM
thyroid gland: 3.6 nTPM
fallopian tube: 3.4 nTPM

Single-cell type

proximal tubule cells: 86 nCPM
choroid plexus epithelial cells: 57 nCPM
ovarian stromal cells: 49 nCPM
rod photoreceptor cells: 42 nCPM
hepatocytes: 34 nCPM
podocytes: 34 nCPM

Immune cell

naive CD4 T-cell: 3 nTPM
naive CD8 T-cell: 2.5 nTPM
naive B-cell: 2.4 nTPM
memory CD8 T-cell: 2 nTPM
T-reg: 2 nTPM
memory CD4 T-cell: 1.9 nTPM

Brain region

cerebellum: 20 nTPM
choroid plexus: 19 nTPM
basal ganglia: 18 nTPM
thalamus: 16 nTPM
hippocampal formation: 16 nTPM
white matter: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFXN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SPSB4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFXN2 as an antibody target. Whether an autoantibody or antibody against SFXN2 could matter depends on whether native SFXN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFXN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SFXN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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