Seroatlas · Human Serome Atlas

SELENOV

Selenoprotein V

Also known as: SELV, SELV_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59797
Gene: SELENOV
Ensembl: ENSG00000186838
Chromosome: 19
Canonical length: 346 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>P59797|SELENOV
     1  MNNQARTPAP SSARTSTSVR ASTPTRTPTP LRTPTPVRTR TPIRTLTPVL TPSPAGTSPL
    61  VLTPAPAQIP TLVPTPALAR IPRLVPPPAP AWIPTPVPTP VPVRNPTPVP TPARTLTPPV
   121  RVPAPAPAQL LAGIRAALPV LDSYLAPALP LDPPPEPAPE LPLLPEEDPE PAPSLKLIPS
   181  VSSEAGPAPG PLPTRTPLAA NSPGPTLDFT FRADPSAIGL ADPPIPSPVP SPILGTIPSA
   241  ISLQNCTETF PSSSENFALD KRVLIRVTYC GLUSYSLRYI LLKKSLEQQF PNHLLFEEDR
   301  AAQATGEFEV FVNGRLVHSK KRGDGFVNES RLQKIVSVID EEIKKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOV can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

testis: 9.4 nTPM
parathyroid gland: 2.2 nTPM
thyroid gland: 1.5 nTPM
retina: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

Single-cell type

late spermatids: 423 nCPM
early spermatids: 102 nCPM
late primary spermatocytes: 68 nCPM
epididymal basal cells: 9.9 nCPM
breast myoepithelial cells: 7.7 nCPM
retinal amacrine cells: 6.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 3.2 nTPM
cerebellum: 3.1 nTPM
medulla oblongata: 3 nTPM
cerebral cortex: 2.5 nTPM
pons: 2.5 nTPM
hypothalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to selenium ion

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SELENOV as an antibody target. Whether an autoantibody or antibody against SELENOV could matter depends on whether native SELENOV is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SELENOV is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SELENOV as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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