Seroatlas · Human Serome Atlas

SELENOT

Thioredoxin reductase-like selenoprotein T

Also known as: SELT, SELT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62341
Gene
SELENOT
Ensembl
ENSG00000198843
Chromosome
3
Canonical length
195 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>P62341|SELENOT
     1  MRLLLLLLVA ASAMVRSEAS ANLGGVPSKR LKMQYATGPL LKFQICVSUG YRRVFEEYMR
    61  VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI IVGKDPFAFF GMQAPSIWQW
   121  GQENKVYACM MVFFLSNMIE NQCMSTGAFE ITLNDVPVWS KLESGHLPSM QQLVQILDNE
   181  MKLNVHMDSI PHHRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 94 nTPM
  • parathyroid gland: 79 nTPM
  • lymph node: 75 nTPM
  • kidney: 70 nTPM
  • adrenal gland: 70 nTPM
  • tonsil: 69 nTPM

Single-cell type

  • syncytiotrophoblasts: 611 nCPM
  • platelets: 324 nCPM
  • neutrophils: 304 nCPM
  • kupffer cells: 292 nCPM
  • extravillous trophoblasts: 280 nCPM
  • plasma cells: 276 nCPM

Immune cell

  • total PBMC: 351 nTPM
  • basophil: 226 nTPM
  • neutrophil: 207 nTPM
  • classical monocyte: 174 nTPM
  • non-classical monocyte: 165 nTPM
  • MAIT T-cell: 156 nTPM

Brain region

  • white matter: 79 nTPM
  • hypothalamus: 76 nTPM
  • spinal cord: 73 nTPM
  • pons: 72 nTPM
  • cerebellum: 71 nTPM
  • thalamus: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0.12
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SELENOT as an antibody target. Whether an autoantibody or antibody against SELENOT could matter depends on whether native SELENOT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SELENOT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SELENOT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SELENOT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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