Seroatlas · Human Serome Atlas

SELENOM

Selenoprotein M

Also known as: SELM, SELM_HUMAN, SEPM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWX9
Gene: SELENOM
Ensembl: ENSG00000198832
Chromosome: 22
Canonical length: 145 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q8WWX9|SELENOM
     1  MSLLLPPLAL LLLLAALVAP ATAATAYRPD WNRLSGLTRA RVETCGGUQL NRLKEVKAFV
    61  TQDIPFYHNL VMKHLPGADP ELVLLGRRYE ELERIPLSEM TREEINALVQ ELGFYRKAAP
   121  DAQVPPEYVW APAKPPEETS DHADL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 875 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 875 nTPM
endometrium: 578 nTPM
colon: 542 nTPM
cervix: 462 nTPM
fallopian tube: 438 nTPM
choroid plexus: 421 nTPM

Single-cell type

smooth muscle cells: 1,486 nCPM
decidual stromal cells: 1,338 nCPM
breast lactating cells: 998 nCPM
vascular smooth muscle cells: 953 nCPM
breast myoepithelial cells: 760 nCPM
late spermatids: 746 nCPM

Immune cell

naive CD4 T-cell: 234 nTPM
T-reg: 180 nTPM
memory CD4 T-cell: 175 nTPM
memory B-cell: 156 nTPM
naive CD8 T-cell: 138 nTPM
MAIT T-cell: 138 nTPM

Brain region

choroid plexus: 252 nTPM
hypothalamus: 166 nTPM
thalamus: 155 nTPM
midbrain: 147 nTPM
spinal cord: 146 nTPM
medulla oblongata: 141 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

oxidoreductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SELENOM as an antibody target. Whether an autoantibody or antibody against SELENOM could matter depends on whether native SELENOM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SELENOM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SELENOM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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