SELENOH

Protein identityUniProt · HPA

UniProt accession

Q8IZQ5

Gene

SELENOH

Ensembl

ENSG00000211450

Chromosome

11

Canonical length

122 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>Q8IZQ5|SELENOH
     1  MAPRGRKRKA EAAVVAVAEK REKLANGGEG MEEATVVIEH CTSURVYGRN AAALSQALRL
    61  EAPELPVKVN PTKPRRGSFE VTLLRPDGSS AELWTGIKKG PPRKLKFPEP QEVVEELKKY
   121  LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENOH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

124 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.86

gnomAD pLI

0

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• RNA binding

Cellular components

• Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

• Selenoprotein, Rdx-type
• Thioredoxin-like superfamily
• Rdx family
• Selenoprotein SelWTH-like

KeywordsUniProt

• Acetylation
• Redox-active center
• Selenocysteine