Seroatlas · Human Serome Atlas

SECISBP2L

Selenocysteine insertion sequence-binding protein 2-like

Also known as: KIAA0256, SBP2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q93073
Gene: SECISBP2L
Ensembl: ENSG00000138593
Chromosome: 15
Canonical length: 1101 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1101 residues, UniProt reviewed canonical sequence.

>Q93073|SECISBP2L
     1  MDRAPTEQNV KLSAEVEPFI PQKKSPDTFM IPMALPNDNG SVSGVEPTPI PSYLITCYPF
    61  VQENQSNRQF PLYNNDIRWQ QPNPNPTGPY FAYPIISAQP PVSTEYTYYQ LMPAPCAQVM
   121  GFYHPFPTPY SNTFQAANTV NAITTECTER PSQLGQVFPL SSHRSRNSNR GSVVPKQQLL
   181  QQHIKSKRPL VKNVATQKET NAAGPDSRSK IVLLVDASQQ TDFPSDIANK SLSETTATML
   241  WKSKGRRRRA SHPTAESSSE QGASEADIDS DSGYCSPKHS NNQPAAGALR NPDSGTMNHV
   301  ESSMCAGGVN WSNVTCQATQ KKPWMEKNQT FSRGGRQTEQ RNNSQVGFRC RGHSTSSERR
   361  QNLQKRPDNK HLSSSQSHRS DPNSESLYFE DEDGFQELNE NGNAKDENIQ QKLSSKVLDD
   421  LPENSPINIV QTPIPITTSV PKRAKSQKKK ALAAALATAQ EYSEISMEQK KLQEALSKAA
   481  GKKNKTPVQL DLGDMLAALE KQQQAMKARQ ITNTRPLSYT VVTAASFHTK DSTNRKPLTK
   541  SQPCLTSFNS VDIASSKAKK GKEKEIAKLK RPTALKKVIL KEREEKKGRL TVDHNLLGSE
   601  EPTEMHLDFI DDLPQEIVSQ EDTGLSMPSD TSLSPASQNS PYCMTPVSQG SPASSGIGSP
   661  MASSTITKIH SKRFREYCNQ VLCKEIDECV TLLLQELVSF QERIYQKDPV RAKARRRLVM
   721  GLREVTKHMK LNKIKCVIIS PNCEKIQSKG GLDEALYNVI AMAREQEIPF VFALGRKALG
   781  RCVNKLVPVS VVGIFNYFGA ESLFNKLVEL TEEARKAYKD MVAAMEQEQA EEALKNVKKV
   841  PHHMGHSRNP SAASAISFCS VISEPISEVN EKEYETNWRN MVETSDGLEA SENEKEVSCK
   901  HSTSEKPSKL PFDTPPIGKQ PSLVATGSTT SATSAGKSTA SDKEEVKPDD LEWASQQSTE
   961  TGSLDGSCRD LLNSSITSTT STLVPGMLEE EEDEDEEEEE DYTHEPISVE VQLNSRIESW
  1021  VSETQRTMET LQLGKTLNGS EEDNVEQSGE EEAEAPEVLE PGMDSEAWTA DQQASPGQQK
  1081  SSNCSSLNKE HSDSNYTTQT T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SECISBP2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 79 nTPM
parathyroid gland: 72 nTPM
cerebral cortex: 45 nTPM
midbrain: 44 nTPM
salivary gland: 42 nTPM
hippocampal formation: 41 nTPM

Single-cell type

syncytiotrophoblasts: 1,821 nCPM
schwann cells: 451 nCPM
oligodendrocytes: 427 nCPM
salivary acinar cells: 350 nCPM
esophageal apical cells: 334 nCPM
cytotrophoblasts: 325 nCPM

Immune cell

eosinophil: 16 nTPM
naive B-cell: 14 nTPM
memory B-cell: 13 nTPM
basophil: 11 nTPM
naive CD4 T-cell: 11 nTPM
neutrophil: 9.9 nTPM

Brain region

white matter: 281 nTPM
basal ganglia: 191 nTPM
medulla oblongata: 189 nTPM
cerebellum: 171 nTPM
spinal cord: 167 nTPM
midbrain: 164 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SECISBP2L.

Disease | ImmuneIEDB

Conditions an epitope on SECISBP2L was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.28
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

selenocysteine incorporation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of SECISBP2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SECISBP2L as an antibody target. Whether an autoantibody or antibody against SECISBP2L could matter depends on whether native SECISBP2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SECISBP2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SECISBP2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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