Seroatlas · Human Serome Atlas

SDK1

Protein sidekick-1

Also known as: FLJ31425, SDK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5N4
Gene: SDK1
Ensembl: ENSG00000146555
Chromosome: 7
Canonical length: 2213 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

2213 residues, UniProt reviewed canonical sequence.

>Q7Z5N4|SDK1
     1  MARGARPSAA GGGGGGAEPP ERAGPGRPRG SPPGRARPSL APRPGPEPSR PRAAPETSGG
    61  DTAGAGRCGG RRAAKLGPGR RGWWALLALQ LHLLRALAQD DVAPYFKTEP GLPQIHLEGN
   121  RLVLTCLAEG SWPLEFKWMR DDSELTTYSS EYKYIIPSLQ KLDAGFYRCV VRNRMGALLQ
   181  RKSEVQVAYM GSFMDTDQRK TVSQGRAAIL NLLPITSYPR PQVTWFREGH KIIPSNRIAI
   241  TLENQLVILA TTTSDAGAYY VQAVNEKNGE NKTSPFIHLS IARDVGTPET MAPTIVVPPG
   301  NRSVVAGSSE TTLECIASAR PVEDLSVTWK RNGVRITSGL HSFGRRLTIS NPTSADTGPY
   361  VCEAALPGSA FEPARATAFL FIIEPPYFTA EPESRISAEV EETVDIGCQA MGVPLPTLQW
   421  YKDAISISRL QNPRYKVLAS GGLRIQKLRP EDSGIFQCFA SNEGGEIQTH TYLDVTNIAP
   481  VFTQRPVDTT VTDGMTAILR CEVSGAPKPA ITWKRENHIL ASGSVRIPRF MLLESGGLQI
   541  APVFIQDAGN YTCYAANTEG SLNASATLTV WNRTSIVHPP EDHVVIKGTT ATLHCGATHD
   601  PRVSLRYVWK KDNVALTPSS TSRIVVEKDG SLLISQTWSG DIGDYSCEIV SEGGNDSRMA
   661  RLEVIELPHS PQNLLVSPNS SHSHAVVLSW VRPFDGNSPI LYYIVELSEN NSPWKVHLSN
   721  VGPEMTGVTV SGLTPARTYQ FRVCAVNEVG RGQYSAETSR LMLPEEPPSA PPKNIVASGR
   781  TNQSIMVQWQ PPPETEHNGV LRGYILRYRL AGLPGEYQQR NITSPEVNYC LVTDLIIWTQ
   841  YEIQVAAYNG AGLGVFSRAV TEYTLQGVPT APPQNVQTEA VNSTTIQFLW NPPPQQFING
   901  INQGYKLLAW PADAPEAVTV VTIAPDFHGV HHGHITNLKK FTAYFTSVLC FTTPGDGPPS
   961  TPQLVWTQED KPGAVGHLSF TEILDTSLKV SWQEPLEKNG IITGYQISWE VYGRNDSRLT
  1021  HTLNSTTHEY KIQGLSSLTT YTIDVAAVTA VGTGLVTSST ISSGVPPDLP GAPSNLVISN
  1081  ISPRSATLQF RPGYDGKTSI SRWIVEGQVG AIGDEEEWVT LYEEENEPDA QMLEIPNLTP
  1141  YTHYRFRMKQ VNIVGPSPYS PSSRVIQTLQ APPDVAPTSV TVRTASETSL RLRWVPLPDS
  1201  QYNGNPESVG YRIKYWRSDL QSSAVAQVVS DRLEREFTIE ELEEWMEYEL QMQAFNAVGA
  1261  GPWSEVVRGR TRESVPSAAP ENVSAEAVSS TQILLTWTSV PEQDQNGLIL GYKILFRAKD
  1321  LDPEPRSHIV RGNHTQSALL AGLRKFVLYE LQVLAFTRIG NGVPSTPLIL ERTKDDAPGP
  1381  PVRLVFPEVR LTSVRIVWQP PEEPNGIILG YQIAYRLASS SPHTFTTVEV GATVRQFTAT
  1441  DLAPESAYIF RLSAKTRQGW GEPLEATVIT TEKRERPAPP RELLVPQAEV TARSLRLQWV
  1501  PGSDGASPIR YFTMQVRELP RGEWQTYSSS ISHEATACVV DRLRPFTSYK LRLKATNDIG
  1561  DSDFSSETEA VTTLQDVPGE PPGSVSATPH TTSSVLIQWQ PPRDESLNGL LQGYRIYYRE
  1621  LEYEAGSGTE AKTLKNPIAL HAELTAQSSF KTVNSSSTST MCELTHLKKY RRYEVIMTAY
  1681  NIIGESPASA PVEVFVGEAA PAMAPQNVQV TPLTASQLEV TWDPPPPESQ NGNIQGYKIY
  1741  YWEADSQNET EKMKVLFLPE PVVRLKNLTS HTKYLVSISA FNAAGDGPKS DPQQGRTHQA
  1801  APGAPSFLAF SEITSTTLNV SWGEPAAANG ILQGYRVVYE PLAPVQGVSK VVTVEVRGNW
  1861  QRWLKVRDLT KGVTYFFRVQ ARTITYGPEL QANITAGPAE GSPGSPRDVL VTKSASELTL
  1921  QWTEGHSGDT PTTGYVIEAR PSDEGLWDMF VKDIPRSATS YTLSLDKLRQ GVTYEFRVVA
  1981  VNEAGYGEPS NPSTAVSAQV EAPFYEEWWF LLVMALSSLI VILLVVFALV LHGQNKKYKN
  2041  CSTGKGISTM EESVTLDNGG FAALELSSRH LNVKSTFSKK NGTRSPPRPS PGGLHYSDED
  2101  ICNKYNGAVL TESVSLKEKS ADASESEATD SDYEDALPKH SFVNHYMSDP TYYNSWKRRA
  2161  QGRAPAPHRY EAVAGSEAGA QLHPVITTQS AGGVYTPAGP GARTPLTGFS SFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

pancreas: 12 nTPM
blood vessel: 10 nTPM
cervix: 8.8 nTPM
choroid plexus: 5.2 nTPM
spleen: 4.9 nTPM
urinary bladder: 4.7 nTPM

Single-cell type

pituicytes/fscs: 2,576 nCPM
endometrial stromal cells: 2,278 nCPM
respiratory secretory cells: 2,023 nCPM
respiratory basal cells: 1,788 nCPM
respiratory deuterosomal cells: 1,463 nCPM
ependymal cells: 1,134 nCPM

Immune cell

neutrophil: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 14 nTPM
hippocampal formation: 12 nTPM
pons: 9.9 nTPM
midbrain: 9 nTPM
medulla oblongata: 8.2 nTPM
cerebral cortex: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0
gnomAD missense Z: -2.1
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDK1 as an antibody target. Whether an autoantibody or antibody against SDK1 could matter depends on whether native SDK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDK1 is annotated at the cell surface, where native SDK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SDK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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