Seroatlas · Human Serome Atlas

SDIM1

Stress-responsive DNAJB4-interacting membrane protein 1

Also known as: SDIM1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZPB5
Gene: SDIM1
Canonical length: 146 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for SDIM1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>Q6ZPB5|SDIM1
     1  MWPAPCSVGR LLIFFMCSSS GYVVQGCGPS PGARTTLGSP LSLWSIKTPS HIFCTRRAIN
    61  LGFPSPPLVQ LIFWSLNAGL DLYLCLISSC GFSQVFWPVE AFCSFSLSFF ALALSHKFVI
   121  CRLDQHIFSG FTKSLKNLPP CHRTDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.47

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.27

OntologyGO

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DNAJB4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDIM1 as an antibody target. Whether an autoantibody or antibody against SDIM1 could matter depends on whether native SDIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDIM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SDIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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