Seroatlas · Human Serome Atlas

SCPEP1

Retinoid-inducible serine carboxypeptidase

Also known as: RISC, RISC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HB40
Gene
SCPEP1
Ensembl
ENSG00000121064
Chromosome
17
Canonical length
452 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in negative regulation of blood pressure and retinoic acid metabolic process. Predicted to act upstream of or within blood vessel diameter maintenance. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q9HB40|SCPEP1
     1  MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVTVRKDAY MFWWLYYATN
    61  SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDSDLKP RKTTWLQAAS LLFVDNPVGT
   121  GFSYVNGSGA YAKDLAMVAS DMMVLLKTFF SCHKEFQTVP FYIFSESYGG KMAAGIGLEL
   181  YKAIQRGTIK CNFAGVALGD SWISPVDSVL SWGPYLYSMS LLEDKGLAEV SKVAEQVLNA
   241  VNKGLYREAT ELWGKAEMII EQNTDGVNFY NILTKSTPTS TMESSLEFTQ SHLVCLCQRH
   301  VRHLQRDALS QLMNGPIRKK LKIIPEDQSW GGQATNVFVN MEEDFMKPVI SIVDELLEAG
   361  INVTVYNGQL DLIVDTMGQE AWVRKLKWPE LPKFSQLKWK ALYSDPKSLE TSAFVKSYKN
   421  LAFYWILKAG HMVPSDQGDM ALKMMRLVTQ QE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCPEP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
283 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 283 nTPM
  • thyroid gland: 127 nTPM
  • adrenal gland: 120 nTPM
  • seminal vesicle: 97 nTPM
  • blood vessel: 90 nTPM
  • lung: 90 nTPM

Single-cell type

  • endometrial secretory cells: 426 nCPM
  • adrenal cortex cells: 388 nCPM
  • submucosal glandular cells: 341 nCPM
  • breast myoepithelial cells: 320 nCPM
  • salivary basal cells: 264 nCPM
  • parietal cells: 262 nCPM

Immune cell

  • eosinophil: 319 nTPM
  • classical monocyte: 228 nTPM
  • non-classical monocyte: 142 nTPM
  • intermediate monocyte: 137 nTPM
  • total PBMC: 118 nTPM
  • myeloid DC: 106 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • white matter: 26 nTPM
  • hypothalamus: 20 nTPM
  • pons: 19 nTPM
  • medulla oblongata: 19 nTPM
  • midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
0.61
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCPEP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCPEP1 as an antibody target. Whether an autoantibody or antibody against SCPEP1 could matter depends on whether native SCPEP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCPEP1 is annotated as secreted, so native SCPEP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SCPEP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCPEP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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