SCG3
Secretogranin-3
Also known as: FLJ90833, SCG3_HUMAN, SgIII
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WXD2
- Gene
- SCG3
- Ensembl
- ENSG00000104112
- Chromosome
- 15
- Canonical length
- 468 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Vesicles
- Secretome location
- Secreted in brain
OverviewNCBI Gene
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Canonical amino-acid sequenceUniProt
468 residues, UniProt reviewed canonical sequence.
>Q8WXD2|SCG3
1 MGFLGTGTWI LVLVLPIQAF PKPGGSQDKS LHNRELSAER PLNEQIAEAE EDKIKKTYPP
61 ENKPGQSNYS FVDNLNLLKA ITEKEKIEKE RQSIRSSPLD NKLNVEDVDS TKNRKLIDDY
121 DSTKSGLDHK FQDDPDGLHQ LDGTPLTAED IVHKIAARIY EENDRAVFDK IVSKLLNLGL
181 ITESQAHTLE DEVAEVLQKL ISKEANNYEE DPNKPTSWTE NQAGKIPEKV TPMAAIQDGL
241 AKGENDETVS NTLTLTNGLE RRTKTYSEDN FEELQYFPNF YALLKSIDSE KEAKEKETLI
301 TIMKTLIDFV KMMVKYGTIS PEEGVSYLEN LDEMIALQTK NKLEKNATDN ISKLFPAPSE
361 KSHEETDSTK EEAAKMEKEY GSLKDSTKDD NSNPGGKTDE PKGKTEAYLE AIRKNIEWLK
421 KHDKKGNKED YDLSKMRDFI NKQADAYVEK GILDKEEAEA IKRIYSSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SCG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 156 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 156 nTPM
- amygdala: 85 nTPM
- basal ganglia: 75 nTPM
- hypothalamus: 64 nTPM
- hippocampal formation: 63 nTPM
- cerebellum: 61 nTPM
Single-cell type
- pancreatic islet cells: 705 nCPM
- bergmann glia: 312 nCPM
- neuroendocrine cells: 150 nCPM
- corticotrophs: 143 nCPM
- oligodendrocyte progenitor cells: 136 nCPM
- cone photoreceptor cells: 122 nCPM
Immune cell
- memory B-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- hypothalamus: 169 nTPM
- cerebral cortex: 144 nTPM
- cerebellum: 109 nTPM
- basal ganglia: 99 nTPM
- midbrain: 89 nTPM
- hippocampal formation: 88 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about SCG3.
Disease | ImmuneIEDB
Conditions an epitope on SCG3 was assayed in.
- type 1 diabetes mellitus T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.66
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.36
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Secretogranin III
- Secretogranin-3
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SCG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SCG3 as an antibody target. Whether an autoantibody or antibody against SCG3 could matter depends on whether native SCG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SCG3 is annotated as secreted, so native SCG3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SCG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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