Seroatlas · Human Serome Atlas

SCD

Stearoyl-CoA desaturase

Also known as: FADS5, SCD_HUMAN, SCD1, SCDOS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00767
Gene
SCD
Ensembl
ENSG00000099194
Chromosome
10
Canonical length
359 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>O00767|SCD
     1  MPAHLLQDDI SSSYTTTTTI TAPPSRVLQN GGDKLETMPL YLEDDIRPDI KDDIYDPTYK
    61  DKEGPSPKVE YVWRNIILMS LLHLGALYGI TLIPTCKFYT WLWGVFYYFV SALGITAGAH
   121  RLWSHRSYKA RLPLRLFLII ANTMAFQNDV YEWARDHRAH HKFSETHADP HNSRRGFFFS
   181  HVGWLLVRKH PAVKEKGSTL DLSDLEAEKL VMFQRRYYKP GLLMMCFILP TLVPWYFWGE
   241  TFQNSVFVAT FLRYAVVLNA TWLVNSAAHL FGYRPYDKNI SPRENILVSL GAVGEGFHNY
   301  HHSFPYDYSA SEYRWHINFT TFFIDCMAAL GLAYDRKKVS KAAILARIKR TGDGNYKSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
1,158 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 1,158 nTPM
  • spinal cord: 979 nTPM
  • liver: 546 nTPM
  • midbrain: 487 nTPM
  • hippocampal formation: 444 nTPM
  • amygdala: 426 nTPM

Single-cell type

  • esophageal apical cells: 705 nCPM
  • alveolar cells type 2: 632 nCPM
  • oligodendrocytes: 541 nCPM
  • esophageal suprabasal cells: 430 nCPM
  • hepatocytes: 250 nCPM
  • kupffer cells: 211 nCPM

Immune cell

  • myeloid DC: 2.7 nTPM
  • MAIT T-cell: 2.3 nTPM
  • intermediate monocyte: 1.6 nTPM
  • plasmacytoid DC: 1.5 nTPM
  • gdT-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.4 nTPM

Brain region

  • white matter: 1,479 nTPM
  • medulla oblongata: 1,398 nTPM
  • pons: 1,088 nTPM
  • spinal cord: 990 nTPM
  • thalamus: 892 nTPM
  • cerebellum: 891 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
2.04
DepMap mean gene effect
-0.82
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCD as an antibody target. Whether an autoantibody or antibody against SCD could matter depends on whether native SCD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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