Seroatlas · Human Serome Atlas

SCARB1

Scavenger receptor class B member 1

Also known as: CD36L1, CLA-1, CLA1, SCRB1_HUMAN, SR-BI, SRB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WTV0
Gene
SCARB1
Ensembl
ENSG00000073060
Chromosome
12
Canonical length
552 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Lysosomes,Rods & Rings

OverviewNCBI Gene

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q8WTV0|SCARB1
     1  MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP
    61  IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ
   121  FQPSKSHGSE SDYIVMPNIL VLGAAVMMEN KPMTLKLIMT LAFTTLGERA FMNRTVGEIM
   181  WGYKDPLVNL INKYFPGMFP FKDKFGLFAE LNNSDSGLFT VFTGVQNISR IHLVDKWNGL
   241  SKVDFWHSDQ CNMINGTSGQ MWPPFMTPES SLEFYSPEAC RSMKLMYKES GVFEGIPTYR
   301  FVAPKTLFAN GSIYPPNEGF CPCLESGIQN VSTCRFSAPL FLSHPHFLNA DPVLAEAVTG
   361  LHPNQEAHSL FLDIHPVTGI PMNCSVKLQL SLYMKSVAGI GQTGKIEPVV LPLLWFAESG
   421  AMEGETLHTF YTQLVLMPKV MHYAQYVLLA LGCVLLLVPV ICQIRSQVGA GQRAARADSH
   481  SLACWGKGAS DRTLWPTAAW SPPPAAVLRL CRSGSGHCWG LRSTLASFAC RVATTLPVLE
   541  GLGPSLGGGT GS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCARB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
236 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 236 nTPM
  • placenta: 105 nTPM
  • liver: 66 nTPM
  • ovary: 27 nTPM
  • adipose tissue: 21 nTPM
  • basal ganglia: 15 nTPM

Single-cell type

  • adrenal cortex cells: 2,251 nCPM
  • müller glia: 224 nCPM
  • pituitary stem cells: 171 nCPM
  • choroid plexus epithelial cells: 160 nCPM
  • hepatocytes: 149 nCPM
  • hofbauer cells: 133 nCPM

Immune cell

  • plasmacytoid DC: 22 nTPM
  • myeloid DC: 9 nTPM
  • classical monocyte: 6.4 nTPM
  • total PBMC: 4 nTPM
  • intermediate monocyte: 3.2 nTPM
  • memory B-cell: 2.4 nTPM

Brain region

  • basal ganglia: 51 nTPM
  • choroid plexus: 50 nTPM
  • thalamus: 36 nTPM
  • hippocampal formation: 30 nTPM
  • amygdala: 29 nTPM
  • pons: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCARB1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 230 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.07
gnomAD missense Z
1.6
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCARB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCARB1 as an antibody target. Whether an autoantibody or antibody against SCARB1 could matter depends on whether native SCARB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCARB1 is annotated at the cell surface, where native SCARB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCARB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCARB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...