Seroatlas · Human Serome Atlas

SCARA5

Scavenger receptor class A member 5

Also known as: FLJ23907, MGC45780, NET33, SCAR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMJ2
Gene: SCARA5
Ensembl: ENSG00000168079
Chromosome: 8
Canonical length: 495 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homotrimer

OverviewNCBI Gene

Predicted to enable ferritin receptor activity. Predicted to be involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Predicted to act upstream of or within cellular response to heat. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q6ZMJ2|SCARA5
     1  MENKAMYLHT VSDCDTSSIC EDSFDGRSLS KLNLCEDGPC HKRRASICCT QLGSLSALKH
    61  AVLGLYLLVF LILVGIFILA VSRPRSSPDD LKALTRNVNR LNESFRDLQL RLLQAPLQAD
   121  LTEQVWKVQD ALQNQSDSLL ALAGAVQRLE GALWGLQAQA VQTEQAVALL RDRTGQQSDT
   181  AQLELYQLQV ESNSSQLLLR RHAGLLDGLA RRVGILGEEL ADVGGVLRGL NHSLSYDVAL
   241  HRTRLQDLRV LVSNASEDTR RLRLAHVGME LQLKQELAML NAVTEDLRLK DWEHSIALRN
   301  ISLAKGPPGP KGDQGDEGKE GRPGIPGLPG LRGLPGERGT PGLPGPKGDD GKLGATGPMG
   361  MRGFKGDRGP KGEKGEKGDR AGDASGVEAP MMIRLVNGSG PHEGRVEVYH DRRWGTVCDD
   421  GWDKKDGDVV CRMLGFRGVE EVYRTARFGQ GTGRIWMDDV ACKGTEETIF RCSFSKWGVT
   481  NCGHAEDASV TCNRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCARA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 87 nTPM
urinary bladder: 82 nTPM
blood vessel: 61 nTPM
adipose tissue: 58 nTPM
colon: 37 nTPM
vagina: 36 nTPM

Single-cell type

fibroblasts: 293 nCPM
fibro-adipogenic progenitors: 264 nCPM
leydig cells: 201 nCPM
decidual stromal cells: 146 nCPM
myosatellite cells: 92 nCPM
adrenal medulla cells: 53 nCPM

Immune cell

plasmacytoid DC: 21 nTPM
myeloid DC: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 10 nTPM
cerebral cortex: 2.2 nTPM
basal ganglia: 1.7 nTPM
cerebellum: 1.7 nTPM
spinal cord: 1.1 nTPM
hypothalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ferritin receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

SRCR domain
Collagen triple helix repeat
SRCR-like domain superfamily
Scavenger receptor cysteine-rich domain
Collagen triple helix repeat (20 copies)
Scavenger receptor class A member 5

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCARA5 as an antibody target. Whether an autoantibody or antibody against SCARA5 could matter depends on whether native SCARA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCARA5 is annotated at the cell surface, where native SCARA5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCARA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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