SARS2

Protein identityUniProt · HPA

UniProt accession

Q9NP81

Gene

SARS2

Ensembl

ENSG00000104835

Chromosome

19

Canonical length

518 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q9NP81|SARS2
     1  MAASMARRLW PLLTRRGFRP RGGCISNDSP RRSFTTEKRN RNLLYEYARE GYSALPQLDI
    61  ERFCACPEEA AHALELRKGE LRSADLPAII STWQELRQLQ EQIRSLEEEK AAVTEAVRAL
   121  LANQDSGEVQ QDPKYQGLRA RGREIRKELV HLYPREAQLE EQFYLQALKL PNQTHPDVPV
   181  GDESQARVLH MVGDKPVFSF QPRGHLEIGE KLDIIRQKRL SHVSGHRSYY LRGAGALLQH
   241  GLVNFTFNKL LRRGFTPMTV PDLLRGAVFE GCGMTPNANP SQIYNIDPAR FKDLNLAGTA
   301  EVGLAGYFMD HTVAFRDLPV RMVCSSTCYR AETNTGQEPR GLYRVHHFTK VEMFGVTGPG
   361  LEQSSQLLEE FLSLQMEILT ELGLHFRVLD MPTQELGLPA YRKFDIEAWM PGRGRFGEVT
   421  SASNCTDFQS RRLHIMFQTE AGELQFAHTV NATACAVPRL LIALLESNQQ KDGSVLVPPA
   481  LQSYLGTDRI TAPTHVPLQY IGPNQPRKPG LPGQPAVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SARS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SARS2.

Disease | AllUniProt

Conditions SARS2 is implicated in, by any mechanism.

• Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome (HUPRAS) MIM:613845

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 412 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hyperuricemia, pulmonary hypertension, renal failure, alkalosis syndrome
• SARS2-associated condition

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.93

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

-0.62

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• seryl-tRNA aminoacylation
• mitochondrial seryl-tRNA aminoacylation

Molecular functions

• ATP binding
• RNA binding
• serine-tRNA ligase activity
• tRNA binding

Cellular components

• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
• Serine-tRNA ligase, type1
• Aminoacyl-tRNA synthetase, class II
• Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
• Serine-tRNA ligase catalytic core domain
• Serine-tRNA synthetase, type1, N-terminal domain superfamily
• Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
• tRNA synthetase class II core domain (G, H, P, S and T)

KeywordsUniProt

• Acetylation
• Aminoacyl-tRNA synthetase
• ATP-binding
• Ligase
• Mitochondrion
• Nucleotide-binding
• Protein biosynthesis
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of SARS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KCMF1