Seroatlas · Human Serome Atlas

SAMTOR

S-adenosylmethionine sensor upstream of mTORC1

Also known as: BMT2, C7orf60, DKFZp762M126, FLJ31818, SAMTR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q1RMZ1
Gene: SAMTOR
Ensembl: ENSG00000164603
Chromosome: 7
Canonical length: 405 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables S-adenosyl-L-methionine binding activity. Involved in cellular response to amino acid starvation; cellular response to methionine; and positive regulation of TORC1 signaling. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>Q1RMZ1|SAMTOR
     1  MEPGAGGRNT ARAQRAGSPN TPPPREQERK LEQEKLSGVV KSVHRRLRKK YREVGDFDKI
    61  WREHCEDEET LCEYAVAMKN LADNHWAKTC EGEGRIEWCC SVCREYFQNG GKRKALEKDE
   121  KRAVLATKTT PALNMHESSQ LEGHLTNLSF TNPEFITELL QASGKIRLLD VGSCFNPFLK
   181  FEEFLTVGID IVPAVESVYK CDFLNLQLQQ PLQLAQDAID AFLKQLKNPI DSLPGELFHV
   241  VVFSLLLSYF PSPYQRWICC KKAHELLVLN GLLLIITPDS SHQNRHAMMM KSWKIAIESL
   301  GFKRFKYSKF SHMHLMAFRK ISLKTTSDLV SRNYPGMLYI PQDFNSIEDE EYSNPSCYVR
   361  SDIEDEQLAY GFTELPDAPY DSDSGESQAS SIPFYELEDP ILLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMTOR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 12 nTPM
retina: 8.6 nTPM
thymus: 7.7 nTPM
testis: 7.5 nTPM
endometrium: 6.8 nTPM
esophagus: 6.8 nTPM

Single-cell type

neutrophils: 202 nCPM
sertoli cells: 162 nCPM
retinal amacrine cells: 138 nCPM
choroid plexus epithelial cells: 129 nCPM
extravillous trophoblasts: 123 nCPM
renal collecting duct principal cells: 120 nCPM

Immune cell

neutrophil: 8.7 nTPM
basophil: 6.8 nTPM
eosinophil: 6.5 nTPM
T-reg: 5.2 nTPM
non-classical monocyte: 4.4 nTPM
naive CD4 T-cell: 4.2 nTPM

Brain region

cerebellum: 16 nTPM
hypothalamus: 16 nTPM
basal ganglia: 13 nTPM
cerebral cortex: 12 nTPM
hippocampal formation: 12 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

S-adenosyl-L-methionine-dependent methyltransferase superfamily
S-adenosylmethionine-dependent methyltransferase Bmt2-like
25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAMTOR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DEPDC5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMTOR as an antibody target. Whether an autoantibody or antibody against SAMTOR could matter depends on whether native SAMTOR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMTOR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMTOR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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