Seroatlas · Human Serome Atlas

SAMD4A

Protein Smaug homolog 1

Also known as: DKFZP434H0350, hSmaug1, KIAA1053, SAMD4, SMAG1_HUMAN, Smaug, SMG, SMGA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UPU9
Gene: SAMD4A
Ensembl: ENSG00000020577
Chromosome: 14
Canonical length: 718 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions,Cytosol

OverviewNCBI Gene

Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q9UPU9|SAMD4A
     1  MMFRDQVGVL AGWFKGWNEC EQTVALLSLL KRVSQTQARF LQLCLEHSLA DCAELHVLER
    61  EANSPGIINQ WQQESKDKVI SLLLTHLPLL KPGNLDAKVE YMKLLPKILA HSIEHNQHIE
   121  ESRQLLSYAL IHPATSLEDR SALAMWLNHL EDRTSTSFGG QNRGRSDSVD YGQTHYYHQR
   181  QNSDDKLNGW QNSRDSGICI NASNWQDKSM GCENGHVPLY SSSSVPTTIN TIGTSTSTIL
   241  SGQAHHSPLK RSVSLTPPMN VPNQPLGHGW MSHEDLRARG PQCLPSDHAP LSPQSSVASS
   301  GSGGSEHLED QTTARNTFQE EGSGMKDVPA WLKSLRLHKY AALFSQMTYE EMMALTECQL
   361  EAQNVTKGAR HKIVISIQKL KERQNLLKSL ERDIIEGGSL RIPLQELHQM ILTPIKAYSS
   421  PSTTPEARRR EPQAPRQPSL MGPESQSPDC KDGAAATGAT ATPSAGASGG LQPHQLSSCD
   481  GELAVAPLPE GDLPGQFTRV MGKVCTQLLV SRPDEENISS YLQLIDKCLI HEAFTETQKK
   541  RLLSWKQQVQ KLFRSFPRKT LLDISGYRQQ RNRGFGQSNS LPTAGSVGGG MGRRNPRQYQ
   601  IPSRNVPSAR LGLLGTSGFV SSNQRNTTAT PTIMKQGRQN LWFANPGGSN SMPSRTHSSV
   661  QRTRSLPVHT SPQNMLMFQQ PEFQLPVTEP DINNRLESLC LSMTEHALGD GVDRTSTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMD4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

testis: 100 nTPM
skeletal muscle: 88 nTPM
spinal cord: 78 nTPM
heart muscle: 45 nTPM
blood vessel: 38 nTPM
tongue: 37 nTPM

Single-cell type

late spermatids: 3,389 nCPM
early spermatids: 1,633 nCPM
myonuclei: 1,444 nCPM
smooth muscle cells: 1,341 nCPM
pituicytes/fscs: 1,142 nCPM
bergmann glia: 1,014 nCPM

Immune cell

intermediate monocyte: 1.2 nTPM
non-classical monocyte: 1 nTPM
myeloid DC: 0.7 nTPM
classical monocyte: 0.6 nTPM
naive B-cell: 0.4 nTPM
total PBMC: 0.2 nTPM

Brain region

medulla oblongata: 158 nTPM
spinal cord: 127 nTPM
white matter: 116 nTPM
pons: 105 nTPM
midbrain: 89 nTPM
thalamus: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 1.84
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAMD4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMD4A as an antibody target. Whether an autoantibody or antibody against SAMD4A could matter depends on whether native SAMD4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMD4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMD4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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