Seroatlas · Human Serome Atlas

SAAL1

Protein SAAL1

Also known as: FLJ41463, SAAL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96ER3
Gene: SAAL1
Ensembl: ENSG00000166788
Chromosome: 11
Canonical length: 474 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Acts upstream of or within positive regulation of synoviocyte proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>Q96ER3|SAAL1
     1  MDRNPSPPPP GRDKEEEEEV AGGDCIGSTV YSKHWLFGVL SGLIQIVSPE NTKSSSDDEE
    61  QLTELDEEME NEICRVWDMS MDEDVALFLQ EFNAPDIFMG VLAKSKCPRL REICVGILGN
   121  MACFQEICVS ISSDKNLGQV LLHCLYDSDP PTLLETSRLL LTCLSQAEVA SVWVERIQEH
   181  PAIYDSICFI MSSSTNVDLL VKVGEVVDKL FDLDEKLMLE WVRNGAAQPL DQPQEESEEQ
   241  PVFRLVPCIL EAAKQVRSEN PEWLDVYMHI LQLLTTVDDG IQAIVHCPDT GKDIWNLLFD
   301  LVCHEFCQSD DPPIILQEQK TVLASVFSVL SAIYASQTEQ EYLKIEKVDL PLIDSLIRVL
   361  QNMEQCQKKP ENSAESNTEE TKRTDLTQDD FHLKILKDIL CEFLSNIFQA LTKETVAQGV
   421  KEGQLSKQKC SSAFQNLLPF YSPVVEDFIK ILREVDKALA DDLEKNFPSL KVQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
tonsil: 15 nTPM
lymph node: 14 nTPM
thymus: 13 nTPM
testis: 12 nTPM
rectum: 11 nTPM

Single-cell type

late primary spermatocytes: 60 nCPM
early primary spermatocytes: 48 nCPM
differentiating spermatogonia: 40 nCPM
esophageal basal cells: 32 nCPM
migrating cytotrophoblasts: 31 nCPM
cytotrophoblasts: 30 nCPM

Immune cell

myeloid DC: 22 nTPM
T-reg: 21 nTPM
memory B-cell: 17 nTPM
memory CD4 T-cell: 16 nTPM
intermediate monocyte: 15 nTPM
non-classical monocyte: 15 nTPM

Brain region

white matter: 8.3 nTPM
cerebellum: 8.2 nTPM
midbrain: 7.9 nTPM
thalamus: 7.2 nTPM
cerebral cortex: 7.1 nTPM
hypothalamus: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of synoviocyte proliferation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SNW1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAAL1 as an antibody target. Whether an autoantibody or antibody against SAAL1 could matter depends on whether native SAAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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