Seroatlas · Human Serome Atlas

S1PR1

Sphingosine 1-phosphate receptor 1

Also known as: CD363, D1S3362, edg-1, EDG1, S1PR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P21453
Gene
S1PR1
Ensembl
ENSG00000170989
Chromosome
1
Canonical length
382 aa
Protein class
Cancer-related genes, CD markers, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>P21453|S1PR1
     1  MGPTSVPLVK AHRSSVSDYV NYDIIVRHYN YTGKLNISAD KENSIKLTSV VFILICCFII
    61  LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR
   121  EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNNFRL FLLISACWVI SLILGGLPIM
   181  GWNCISALSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN
   241  ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKVKTCDIL FRAEYFLVLA
   301  VLNSGTNPII YTLTNKEMRR AFIRIMSCCK CPSGDSAGKF KRPIIAGMEF SRSKSDNSSH
   361  PQKDEGDNPE TIMSSGNVNS SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S1PR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
122 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 122 nTPM
  • breast: 99 nTPM
  • lung: 80 nTPM
  • heart muscle: 73 nTPM
  • spleen: 59 nTPM
  • basal ganglia: 59 nTPM

Single-cell type

  • vascular endothelial cells: 165 nCPM
  • lymphatic endothelial cells: 102 nCPM
  • bergmann glia: 71 nCPM
  • astrocytes: 41 nCPM
  • müller glia: 37 nCPM
  • hofbauer cells: 28 nCPM

Immune cell

  • basophil: 1,252 nTPM
  • gdT-cell: 591 nTPM
  • memory CD4 T-cell: 504 nTPM
  • memory CD8 T-cell: 492 nTPM
  • MAIT T-cell: 442 nTPM
  • total PBMC: 439 nTPM

Brain region

  • thalamus: 131 nTPM
  • midbrain: 124 nTPM
  • hypothalamus: 105 nTPM
  • medulla oblongata: 104 nTPM
  • basal ganglia: 98 nTPM
  • pons: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.73
gnomAD missense Z
2.61
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S1PR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S1PR1 as an antibody target. Whether an autoantibody or antibody against S1PR1 could matter depends on whether native S1PR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S1PR1 is annotated at the cell surface, where native S1PR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label S1PR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S1PR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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