Seroatlas · Human Serome Atlas

S100A14

Protein S100-A14

Also known as: BCMP84, S100A15, S10AE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCY8
Gene: S100A14
Ensembl: ENSG00000189334
Chromosome: 1
Canonical length: 104 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear bodies,Plasma membrane,Cell Junctions,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

104 residues, UniProt reviewed canonical sequence.

>Q9HCY8|S100A14
     1  MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS
    61  NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP VRGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100A14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 3,630 nTPM

Expression across tissuesHPA

Tissue

esophagus: 3,630 nTPM
vagina: 1,168 nTPM
cervix: 790 nTPM
skin: 585 nTPM
salivary gland: 510 nTPM
tonsil: 422 nTPM

Single-cell type

esophageal apical cells: 56,119 nCPM
esophageal suprabasal cells: 16,152 nCPM
esophageal basal cells: 4,906 nCPM
suprabasal keratinocytes: 4,304 nCPM
basal keratinocytes: 1,951 nCPM
colonocytes: 1,436 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 1 nTPM
basal ganglia: 0.8 nTPM
cerebral cortex: 0.7 nTPM
amygdala: 0.6 nTPM
medulla oblongata: 0.6 nTPM
white matter: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S100A14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AGER

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S100A14 as an antibody target. Whether an autoantibody or antibody against S100A14 could matter depends on whether native S100A14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S100A14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label S100A14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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