Seroatlas · Human Serome Atlas

RTL8C

CAAX box protein 1

Also known as: CXX1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15255
Gene: RTL8C
Canonical length: 209 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RTL8C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>O15255|RTL8C
     1  MGGGRGLLGR ETLGPGGGCS GEGPLCYWPP PGSPPAPSLR ASLPLEPPRC PLRSCSLPRS
    61  ACLCSRNSAP GSCCRPWASL WSEPPPSPSS QPAPPMYIWT LSCAPAASWA PVTHWTDHPL
   121  PPLPSPLLPT RLPDDYIILP TDLRCHSHRH PSHPTDRLLL LVIWTHLGGI WAGHSPWTVI
   181  QTAGRPPRDL SPSARPISSP PPETSCVLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL8C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 427 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 427 nTPM
cerebral cortex: 392 nTPM
hypothalamus: 375 nTPM
amygdala: 349 nTPM
midbrain: 336 nTPM
basal ganglia: 336 nTPM

Single-cell type

esophageal suprabasal cells: 272 nCPM
esophageal apical cells: 250 nCPM
hepatic stellate cells: 226 nCPM
decidual stromal cells: 225 nCPM
peritubular myoid cells: 135 nCPM
cytotrophoblasts: 127 nCPM

Immune cell

intermediate monocyte: 91 nTPM
non-classical monocyte: 78 nTPM
classical monocyte: 74 nTPM
eosinophil: 68 nTPM
plasmacytoid DC: 58 nTPM
myeloid DC: 54 nTPM

Brain region

midbrain: 304 nTPM
pons: 293 nTPM
hypothalamus: 288 nTPM
medulla oblongata: 267 nTPM
cerebral cortex: 263 nTPM
basal ganglia: 262 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

CAAX box protein 1
CAAX box cerebral protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RTL8C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL8C as an antibody target. Whether an autoantibody or antibody against RTL8C could matter depends on whether native RTL8C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL8C is annotated at the cell surface, where native RTL8C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RTL8C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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