Seroatlas · Human Serome Atlas

RTL8B

Retrotransposon Gag-like protein 8B

Also known as: CXX1c, FAM127C, MAR8B, RTL8B_HUMAN, SIRH4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q17RB0
Gene
RTL8B
Ensembl
ENSG00000212747
Chromosome
X
Canonical length
113 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RTL8B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q17RB0|RTL8B
     1  MEGRVQLMKA LLARPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY MFVDENTFSN
    61  DALKVTFLIT RLTGPALQWV IPYIKKESPL LSDYRGFLAE MKRVFGWEED EDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTL8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 30 nTPM
  • adrenal gland: 21 nTPM
  • endometrium: 20 nTPM
  • esophagus: 19 nTPM
  • heart muscle: 18 nTPM
  • urinary bladder: 18 nTPM

Single-cell type

  • cytotrophoblasts: 128 nCPM
  • migrating cytotrophoblasts: 76 nCPM
  • esophageal suprabasal cells: 58 nCPM
  • esophageal basal cells: 41 nCPM
  • decidual stromal cells: 38 nCPM
  • esophageal apical cells: 37 nCPM

Immune cell

  • classical monocyte: 1.6 nTPM
  • non-classical monocyte: 1.6 nTPM
  • intermediate monocyte: 1 nTPM
  • myeloid DC: 0.9 nTPM
  • total PBMC: 0.8 nTPM
  • plasmacytoid DC: 0.6 nTPM

Brain region

  • medulla oblongata: 13 nTPM
  • hypothalamus: 13 nTPM
  • basal ganglia: 13 nTPM
  • cerebral cortex: 13 nTPM
  • pons: 13 nTPM
  • spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0.01
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of RTL8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTL8B as an antibody target. Whether an autoantibody or antibody against RTL8B could matter depends on whether native RTL8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTL8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTL8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RTL8B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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