RSL24D1

Protein identityUniProt · HPA

UniProt accession

Q9UHA3

Gene

RSL24D1

Ensembl

ENSG00000137876

Chromosome

15

Canonical length

163 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q9UHA3|RSL24D1
     1  MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG
    61  KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK
   121  VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSL24D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

225 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.88

gnomAD missense Z

0.26

DepMap mean gene effect

-2.07

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ribosomal large subunit biogenesis

Molecular functions

• structural constituent of ribosome

Cellular components

• nucleolus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein eL24-related, N-terminal
• TRASH domain
• Large ribosomal subunit protein eL24, conserved site
• Ribosomal protein L24e/L24 superfamily
• Large ribosomal subunit protein eL24
• Ribosomal protein L24e
• Large ribosomal subunit protein eL24-like, archaea

KeywordsUniProt

• Nucleus
• Ribosome biogenesis

InteractionsUniProt · HPA

Protein binding partners of RSL24D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RPL3