RRBP1

Protein identityUniProt · HPA

UniProt accession

Q9P2E9

Gene

RRBP1

Ensembl

ENSG00000125844

Chromosome

20

Canonical length

1410 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

1410 residues, UniProt reviewed canonical sequence.

>Q9P2E9|RRBP1
     1  MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA KTHHQKVEKK
    61  KKEKTVEKKG KTKKKEEKPN GKIPDHDPAP NVTVLLREPV RAPAVAVAPT PVQPPIIVAP
   121  VATVPAMPQE KLASSPKDKK KKEKKVAKVE PAVSSVVNSI QVLTSKAAIL ETAPKEVPMV
   181  VVPPVGAKGN TPATGTTQGK KAEGTQNQSK KAEGAPNQGR KAEGTPNQGK KTEGTPNQGK
   241  KAEGTPNQGK KAEGTPNQGK KAEGAQNQGK KVDTTPNQGK KVEGAPTQGR KAEGAQNQAK
   301  KVEGAQNQGK KAEGAQNQGK KGEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK
   361  KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK KAEGAQNQGK KAEGAQNQGK
   421  KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK
   481  KAEGAQNQGK KAEGAQNQGK KAEGAQNQGQ KGEGAQNQGK KTEGAQGKKA ERSPNQGKKG
   541  EGAPIQGKKA DSVANQGTKV EGITNQGKKA EGSPSEGKKA EGSPNQGKKA DAAANQGKKT
   601  ESASVQGRNT DVAQSPEAPK QEAPAKKKSG SKKKGEPGPP DADGPLYLPY KTLVSTVGSM
   661  VFNEGEAQRL IEILSEKAGI IQDTWHKATQ KGDPVAILKR QLEEKEKLLA TEQEDAAVAK
   721  SKLRELNKEM AAEKAKAAAG EAKVKKQLVA REQEITAVQA RMQASYREHV KEVQQLQGKI
   781  RTLQEQLENG PNTQLARLQQ ENSILRDALN QATSQVESKQ NAELAKLRQE LSKVSKELVE
   841  KSEAVRQDEQ QRKALEAKAA AFEKQVLQLQ ASHRESEEAL QKRLDEVSRE LCHTQSSHAS
   901  LRADAEKAQE QQQQMAELHS KLQSSEAEVR SKCEELSGLH GQLQEARAEN SQLTERIRSI
   961  EALLEAGQAR DAQDVQASQA EADQQQTRLK ELESQVSGLE KEAIELREAV EQQKVKNNDL
  1021  REKNWKAMEA LATAEQACKE KLLSLTQAKE ESEKQLCLIE AQTMEALLAL LPELSVLAQQ
  1081  NYTEWLQDLK EKGPTLLKHP PAPAEPSSDL ASKLREAEET QSTLQAECDQ YRSILAETEG
  1141  MLRDLQKSVE EEEQVWRAKV GAAEEELQKS RVTVKHLEEI VEKLKGELES SDQVREHTSH
  1201  LEAELEKHMA AASAECQNYA KEVAGLRQLL LESQSQLDAA KSEAQKQSDE LALVRQQLSE
  1261  MKSHVEDGDI AGAPASSPEA PPAEQDPVQL KTQLEWTEAI LEDEQTQRQK LTAEFEEAQT
  1321  SACRLQEELE KLRTAGPLES SETEEASQLK ERLEKEKKLT SDLGRAATRL QELLKTTQEQ
  1381  LAREKDTVKK LQEQLEKAED GSSSKEGTSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

470 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RRBP1.

Disease | ImmuneIEDB

Conditions an epitope on RRBP1 was assayed in.

• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.68

gnomAD pLI

0

gnomAD missense Z

0.05

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• osteoblast differentiation
• protein transport
• translation

Molecular functions

• RNA binding
• signaling receptor activity

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• membrane
• ribosome

Protein domainsUniProt · Pfam · InterPro

• Ribosome receptor lysine/proline rich
• Ribosome receptor lysine/proline rich region
• Ribosome-binding protein 1

KeywordsUniProt

• Acetylation
• Endoplasmic reticulum
• Isopeptide bond
• Membrane
• Phosphoprotein
• Protein transport
• Repeat
• Translocation
• Transmembrane
• Transmembrane helix
• Transport
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of RRBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANK2
• ZWINT