Seroatlas · Human Serome Atlas

RPS6KB2

Ribosomal protein S6 kinase beta-2

Also known as: KLS, KS6B2_HUMAN, P70-BETA, p70S6Kb, S6KB, S6Kbeta, STK14B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBS0
Gene: RPS6KB2
Ensembl: ENSG00000175634
Chromosome: 11
Canonical length: 482 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q9UBS0|RPS6KB2
     1  MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL TETSVNVGPE
    61  RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTRAER
   121  NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL
   181  ALGHLHSQGI IYRDLKPENI MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI
   241  LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIRGKLALPP YLTPDARDLV
   301  KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ SEEDVSQFDT
   361  RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRA
   421  PVSPLKFSPF EGFRPSPSLP EPTELPLPPL LPPPPPSTTA PLPIRPPSGT KKSKRGRGRP
   481  GR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6KB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

skin: 78 nTPM
esophagus: 70 nTPM
liver: 49 nTPM
skeletal muscle: 36 nTPM
pancreas: 34 nTPM
stomach: 34 nTPM

Single-cell type

esophageal apical cells: 358 nCPM
esophageal suprabasal cells: 323 nCPM
esophageal basal cells: 161 nCPM
suprabasal keratinocytes: 154 nCPM
syncytiotrophoblasts: 123 nCPM
extravillous trophoblasts: 109 nCPM

Immune cell

non-classical monocyte: 50 nTPM
myeloid DC: 44 nTPM
intermediate monocyte: 43 nTPM
classical monocyte: 37 nTPM
total PBMC: 37 nTPM
T-reg: 35 nTPM

Brain region

choroid plexus: 14 nTPM
white matter: 10 nTPM
medulla oblongata: 9.5 nTPM
basal ganglia: 9.3 nTPM
midbrain: 8.2 nTPM
spinal cord: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS6KB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CSNK2B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS6KB2 as an antibody target. Whether an autoantibody or antibody against RPS6KB2 could matter depends on whether native RPS6KB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS6KB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS6KB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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