RPS4Y2

Protein identityUniProt · HPA

UniProt accession

Q8TD47

Gene

RPS4Y2

Ensembl

ENSG00000280969

Chromosome

Y

Canonical length

263 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in the male-specific region of the Y chromosome. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q8TD47|RPS4Y2
     1  MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE
    61  VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR LVYNTKGCFA VHRITVEEAK
   121  YKLCKVRKIT VGTKGIPHLV THDARTIRYP DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV
   181  CMVIAGANLG RVGVITNRER HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR
   241  GKGIRLTIAE ERDKRLAAKQ SSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS4Y2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

1.8 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.92

gnomAD pLI

0

gnomAD missense Z

-1.01

DepMap mean gene effect

0.47

DepMap dependency class

none

OntologyGO

Biological processes

• translation

Molecular functions

• RNA binding
• rRNA binding
• structural constituent of ribosome

Cellular components

• cytosolic small ribosomal subunit

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein eS4
• KOW
• Small ribosomal subunit protein eS4, N-terminal
• Small ribosomal subunit protein eS4, central region
• Large ribosomal subunit protein uL2, domain 2
• Small ribosomal subunit protein eS4, N-terminal, conserved site
• Small ribosomal subunit protein eS4, C-terminal domain
• RNA-binding S4 domain superfamily
• Small ribosomal subunit protein eS4, central domain superfamily
• Small ribosomal subunit protein eS4, KOW domain
• KOW motif
• Ribosomal family S4e
• RS4NT (NUC023) domain
• 40S ribosomal protein S4 C-terminus

KeywordsUniProt

• Ribonucleoprotein
• Ribosomal protein
• RNA-binding
• rRNA-binding

InteractionsUniProt · HPA

Protein binding partners of RPS4Y2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RPS4Y1