RPS4Y1

Protein identityUniProt · HPA

UniProt accession

P22090

Gene

RPS4Y1

Ensembl

ENSG00000129824

Chromosome

Y

Canonical length

263 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>P22090|RPS4Y1
     1  MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE
    61  VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITVEEAK
   121  YKLCKVRKIT VGVKGIPHLV THDARTIRYP DPVIKVNDTV QIDLGTGKII NFIKFDTGNL
   181  CMVIGGANLG RVGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR
   241  GKGIRLTVAE ERDKRLATKQ SSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS4Y1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

357 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0.63

gnomAD missense Z

1.12

DepMap mean gene effect

0.21

DepMap dependency class

none

OntologyGO

Biological processes

• translation

Molecular functions

• RNA binding
• rRNA binding
• structural constituent of ribosome

Cellular components

• cytosol
• cytosolic small ribosomal subunit
• membrane
• nucleoplasm
• nucleus
• ribosome

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein eS4
• RNA-binding S4 domain
• KOW
• Small ribosomal subunit protein eS4, N-terminal
• Small ribosomal subunit protein eS4, central region
• Large ribosomal subunit protein uL2, domain 2
• Small ribosomal subunit protein eS4, N-terminal, conserved site
• Small ribosomal subunit protein eS4, C-terminal domain
• RNA-binding S4 domain superfamily
• Small ribosomal subunit protein eS4, central domain superfamily
• Small ribosomal subunit protein eS4, KOW domain
• KOW motif
• Ribosomal family S4e
• RS4NT (NUC023) domain
• 40S ribosomal protein S4 C-terminus

KeywordsUniProt

• Ribonucleoprotein
• Ribosomal protein
• RNA-binding
• rRNA-binding

InteractionsUniProt · HPA

Protein binding partners of RPS4Y1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RPS4Y2