Seroatlas · Human Serome Atlas

RPS27

Small ribosomal subunit protein eS27

Also known as: MPS-1, MPS1, RS27_HUMAN, S27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P42677
Gene
RPS27
Ensembl
ENSG00000177954
Chromosome
1
Canonical length
84 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]

Canonical amino-acid sequenceUniProt

84 residues, UniProt reviewed canonical sequence.

>P42677|RPS27
     1  MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS
    61  TVLCQPTGGK ARLTEGCSFR RKQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
12,191 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 12,191 nTPM
  • tonsil: 8,558 nTPM
  • breast: 8,082 nTPM
  • thymus: 7,890 nTPM
  • pancreas: 7,246 nTPM
  • skin: 7,215 nTPM

Single-cell type

  • late spermatids: 13,569 nCPM
  • ovarian stromal cells: 12,431 nCPM
  • decidual stromal cells: 10,149 nCPM
  • gastric chief cells: 10,038 nCPM
  • hepatocytes: 9,027 nCPM
  • suprabasal keratinocytes: 8,931 nCPM

Immune cell

  • total PBMC: 76,733 nTPM
  • memory B-cell: 57,242 nTPM
  • naive CD4 T-cell: 53,872 nTPM
  • naive B-cell: 49,011 nTPM
  • memory CD4 T-cell: 43,212 nTPM
  • naive CD8 T-cell: 42,471 nTPM

Brain region

  • hypothalamus: 563 nTPM
  • medulla oblongata: 525 nTPM
  • basal ganglia: 496 nTPM
  • white matter: 484 nTPM
  • midbrain: 460 nTPM
  • thalamus: 447 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS27.

Disease | AllUniProt

Conditions RPS27 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 54 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diamond-Blackfan anemia 17

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.76
gnomAD missense Z
0.93

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS27 as an antibody target. Whether an autoantibody or antibody against RPS27 could matter depends on whether native RPS27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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