Seroatlas · Human Serome Atlas

RPRD2

Regulation of nuclear pre-mRNA domain-containing protein 2

Also known as: FLJ32145, HSPC099, KIAA0460, RPRD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VT52
Gene: RPRD2
Ensembl: ENSG00000163125
Chromosome: 1
Canonical length: 1461 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1461 residues, UniProt reviewed canonical sequence.

>Q5VT52|RPRD2
     1  MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE NKKHHSTIVY
    61  HWMKWLRRSA YPHRLNLFYL ANDVIQNCKR KNAIIFRESF ADVLPEAAAL VKDPSVSKSV
   121  ERIFKIWEDR NVYPEEMIVA LREALSTTFK TQKQLKENLN KQPNKQWKKS QTSTNPKAAL
   181  KSKIVAEFRS QALIEELLLY KRSEDQIELK EKQLSTMRVD VCSTETLKCL KDKTGGKKFS
   241  KEFEEASSKL EEFVNGLDKQ VKNGPSLTEA LENAGIFYEA QYKEVKVVAN AYKTFANRVN
   301  NLKKKLDQLK STLPDPEESP VPSPSMDAPS PTGSESPFQG MGGEESQSPT MESEKSATPE
   361  PVTDNRDVED MELSDVEDDG SKIIVEDRKE KPAEKSAVST SVPTKPTENI SKASSCTPVP
   421  VTMTATPPLP KPVNTSLSPS PALALPNLAN VDLAKISSIL SSLTSVMKNT GVSPASRPSP
   481  GTPTSPSNLT SGLKTPAPAT TTSHNPLANI LSKVEITPES ILSALSKTQT QSAPALQGLS
   541  SLLQSVTGNP VPASEAASQS TSASPANTTV STIKGRNLPS SAQPFIPKSF NYSPNSSTSE
   601  VSSTSASKAS IGQSPGLPST TFKLPSNSLG FTATHNTSPA APPTEVTICQ SSEVSKPKLE
   661  SESTSPSLEM KIHNFLKGNP GFSGLNLNIP ILSSLGSSAP SESHPSDFQR GPTSTSIDNI
   721  DGTPVRDERS GTPTQDEMMD KPTSSSVDTM SLLSKIISPG SSTPSSTRSP PPGRDESYPR
   781  ELSNSVSTYR PFGLGSESPY KQPSDGMERP SSLMDSSQEK FYPDTSFQED EDYRDFEYSG
   841  PPPSAMMNLE KKPAKSILKS SKLSDTTEYQ PILSSYSHRA QEFGVKSAFP PSVRALLDSS
   901  ENCDRLSSSP GLFGAFSVRG NEPGSDRSPS PSKNDSFFTP DSNHNSLSQS TTGHLSLPQK
   961  QYPDSPHPVP HRSLFSPQNT LAAPTGHPPT SGVEKVLAST ISTTSTIEFK NMLKNASRKP
  1021  SDDKHFGQAP SKGTPSDGVS LSNLTQPSLT ATDQQQQEEH YRIETRVSSS CLDLPDSTEE
  1081  KGAPIETLGY HSASNRRMSG EPIQTVESIR VPGKGNRGHG REASRVGWFD LSTSGSSFDN
  1141  GPSSASELAS LGGGGSGGLT GFKTAPYKER APQFQESVGS FRSNSFNSTF EHHLPPSPLE
  1201  HGTPFQREPV GPSSAPPVPP KDHGGIFSRD APTHLPSVDL SNPFTKEAAL AHAAPPPPPG
  1261  EHSGIPFPTP PPPPPPGEHS SSGGSGVPFS TPPPPPPPVD HSGVVPFPAP PLAEHGVAGA
  1321  VAVFPKDHSS LLQGTLAEHF GVLPGPRDHG GPTQRDLNGP GLSRVRESLT LPSHSLEHLG
  1381  PPHGGGGGGG SNSSSGPPLG PSHRDTISRS GIILRSPRPD FRPREPFLSR DPFHSLKRPR
  1441  PPFARGPPFF APKRPFFPPR Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPRD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 15 nTPM
retina: 12 nTPM
cerebellum: 11 nTPM
ovary: 11 nTPM
thyroid gland: 11 nTPM
blood vessel: 10 nTPM

Single-cell type

myonuclei: 371 nCPM
thyrotrophs: 311 nCPM
lactotrophs: 293 nCPM
somatotrophs: 268 nCPM
corticotrophs: 245 nCPM
retinal amacrine cells: 234 nCPM

Immune cell

T-reg: 4.9 nTPM
naive CD8 T-cell: 4.3 nTPM
non-classical monocyte: 4.3 nTPM
basophil: 4.1 nTPM
naive CD4 T-cell: 4.1 nTPM
naive B-cell: 3.9 nTPM

Brain region

cerebellum: 30 nTPM
hypothalamus: 21 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 19 nTPM
white matter: 19 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.06
gnomAD pLI: 1
gnomAD missense Z: 2.12
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mRNA 3'-end processing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

CID domain
ENTH/VHS
CID domain
RPRD2, CID domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPRD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUPT5H

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPRD2 as an antibody target. Whether an autoantibody or antibody against RPRD2 could matter depends on whether native RPRD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPRD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPRD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...