RPL39

Protein identityUniProt · HPA

UniProt accession

P62891

Gene

RPL39

Ensembl

ENSG00000198918

Chromosome

X

Canonical length

51 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

51 residues, UniProt reviewed canonical sequence.

>P62891|RPL39
     1  MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

5,244 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.1

gnomAD pLI

0.58

gnomAD missense Z

1.33

DepMap mean gene effect

-0.65

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antibacterial humoral response
• antimicrobial humoral immune response mediated by antimicrobial peptide
• cytoplasmic translation
• defense response to Gram-positive bacterium
• innate immune response in mucosa
• translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• cytosol
• cytosolic large ribosomal subunit
• cytosolic ribosome
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein eL39
• Large ribosomal subunit protein eL39, conserved site
• Large ribosomal subunit protein eL39 domain superfamily
• Ribosomal L39 protein

KeywordsUniProt

• Cytoplasm
• Ribonucleoprotein
• Ribosomal protein

InteractionsUniProt · HPA

Protein binding partners of RPL39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IMPACT