Seroatlas · Human Serome Atlas

RORC

Nuclear receptor ROR-gamma

Also known as: NR1F3, RORG, RORG_HUMAN, RZRG, TOR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51449
Gene
RORC
Ensembl
ENSG00000143365
Chromosome
1
Canonical length
518 aa
Protein class
Disease related genes, Human disease related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location
Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>P51449|RORC
     1  MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQR
    61  CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK
   121  QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS
   181  GSGPSYSNNL AKAGLNGASC HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG
   241  LGELGQGPDS YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF
   301  SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI VLLKAGAMEV
   361  VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI FDFSHSLSAL HFSEDEIALY
   421  TALVLINAHR PGLQEKRKVE QLQYNLELAF HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV
   481  ERLQIFQHLH PIVVQAAFPP LYKELFSTET ESPVGLSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RORC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 100 nTPM
  • liver: 63 nTPM
  • tongue: 52 nTPM
  • pancreas: 51 nTPM
  • thymus: 47 nTPM
  • salivary gland: 38 nTPM

Single-cell type

  • breast lactating cells: 111 nCPM
  • myonuclei: 76 nCPM
  • hepatocytes: 66 nCPM
  • tuft cells: 58 nCPM
  • innate lymphoid cells: 53 nCPM
  • enterocytes: 45 nCPM

Immune cell

  • MAIT T-cell: 50 nTPM
  • memory CD4 T-cell: 7.9 nTPM
  • memory CD8 T-cell: 7.2 nTPM
  • T-reg: 5.8 nTPM
  • gdT-cell: 3.4 nTPM
  • total PBMC: 1.2 nTPM

Brain region

  • choroid plexus: 8.4 nTPM
  • cerebellum: 4.3 nTPM
  • midbrain: 2.5 nTPM
  • spinal cord: 1.2 nTPM
  • medulla oblongata: 1 nTPM
  • pons: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RORC.

Disease | AllUniProt

Conditions RORC is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 361 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
2.29
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RORC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RORC as an antibody target. Whether an autoantibody or antibody against RORC could matter depends on whether native RORC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RORC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RORC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RORC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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