Seroatlas · Human Serome Atlas

ARID5A

AT-rich interactive domain-containing protein 5A

Also known as: ARI5A_HUMAN, MRF-1, RP11-363D14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03989
Gene
ARID5A
Ensembl
ENSG00000196843
Chromosome
2
Canonical length
594 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q03989|ARID5A
     1  MAAPVKGNRK QSTEGDALDP PASPKPAGKQ NGIQNPISLE DSPEAGGERE EEQEREEEQA
    61  FLVSLYKFMK ERHTPIERVP HLGFKQINLW KIYKAVEKLG AYELVTGRRL WKNVYDELGG
   121  SPGSTSAATC TRRHYERLVL PYVRHLKGED DKPLPTSKPR KQYKMAKENR GDDGATERPK
   181  KAKEERRMDQ MMPGKTKADA ADPAPLPSQE PPRNSTEQQG LASGSSVSFV GASGCPEAYK
   241  RLLSSFYCKG THGIMSPLAK KKLLAQVSKV EALQCQEEGC RHGAEPQASP AVHLPESPQS
   301  PKGLTENSRH RLTPQEGLQA PGGSLREEAQ AGPCPAAPIF KGCFYTHPTE VLKPVSQHPR
   361  DFFSRLKDGV LLGPPGKEGL SVKEPQLVWG GDANRPSAFH KGGSRKGILY PKPKACWVSP
   421  MAKVPAESPT LPPTFPSSPG LGSKRSLEEE GAAHSGKRLR AVSPFLKEAD AKKCGAKPAG
   481  SGLVSCLLGP ALGPVPPEAY RGTMLHCPLN FTGTPGPLKG QAALPFSPLV IPAFPAHFLA
   541  TAGPSPMAAG LMHFPPTSFD SALRHRLCPA SSAWHAPPVT TYAAPHFFHL NTKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARID5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 79 nTPM
  • lung: 46 nTPM
  • breast: 39 nTPM
  • fallopian tube: 32 nTPM
  • adipose tissue: 31 nTPM
  • heart muscle: 27 nTPM

Single-cell type

  • smooth muscle cells: 271 nCPM
  • neutrophils: 220 nCPM
  • breast secretory cells: 209 nCPM
  • vascular smooth muscle cells: 141 nCPM
  • vascular endothelial cells: 136 nCPM
  • schwann cells: 128 nCPM

Immune cell

  • eosinophil: 33 nTPM
  • NK-cell: 28 nTPM
  • neutrophil: 22 nTPM
  • plasmacytoid DC: 19 nTPM
  • T-reg: 16 nTPM
  • gdT-cell: 15 nTPM

Brain region

  • medulla oblongata: 21 nTPM
  • pons: 16 nTPM
  • midbrain: 14 nTPM
  • spinal cord: 14 nTPM
  • thalamus: 13 nTPM
  • cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.95
gnomAD missense Z
1.67
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARID5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARID5A as an antibody target. Whether an autoantibody or antibody against ARID5A could matter depends on whether native ARID5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARID5A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARID5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARID5A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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