Seroatlas · Human Serome Atlas

RNF6

E3 ubiquitin-protein ligase RNF6

Also known as: DKFZp686P0776, RNF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y252
Gene: RNF6
Ensembl: ENSG00000127870
Chromosome: 13
Canonical length: 685 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nuclear membrane

OverviewNCBI Gene

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

685 residues, UniProt reviewed canonical sequence.

>Q9Y252|RNF6
     1  MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL
    61  LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV PRESSHEDSL LEWLNTFRRT
   121  GNATRSGQNG NQTWRAVSRT NPNNGEFRFS LEIHVNHENR GFEIHGEDYT DIPLSDSNRD
   181  HTANRQQRST SPVARRTRSQ TSVNFNGSSS NIPRTRLASR GQNPAEGSFS TLGRLRNGIG
   241  GAAGIPRANA SRTNFSSHTN QSGGSELRQR EGQRFGAAHV WENGARSNVT VRNTNQRLEP
   301  IRLRSTSNSR SRSPIQRQSG TVYHNSQRES RPVQQTTRRS VRRRGRTRVF LEQDRERERR
   361  GTAYTPFSNS RLVSRITVEE GEESSRSSTA VRRHPTITLD LQVRRIRPGE NRDRDSIANR
   421  TRSRVGLAEN TVTIESNSGG FRRTISRLER SGIRTYVSTI TVPLRRISEN ELVEPSSVAL
   481  RSILRQIMTG FGELSSLMEA DSESELQRNG QHLPDMHSEL SNLGTDNNRS QHREGSSQDR
   541  QAQGDSTEMH GENETTQPHT RNSDSRGGRQ LRNPNNLVET GTLPILRLAH FFLLNESDDD
   601  DRIRGLTKEQ IDNLSTRHYE HNSIDSELGK ICSVCISDYV TGNKLRQLPC MHEFHIHCID
   661  RWLSENCTCP ICRQPVLGSN IANNG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
bone marrow: 31 nTPM
retina: 25 nTPM
thymus: 24 nTPM
tonsil: 22 nTPM
parathyroid gland: 21 nTPM

Single-cell type

late spermatids: 238 nCPM
late primary spermatocytes: 164 nCPM
early spermatids: 97 nCPM
syncytiotrophoblasts: 60 nCPM
respiratory ciliated cells: 57 nCPM
early primary spermatocytes: 57 nCPM

Immune cell

basophil: 47 nTPM
eosinophil: 35 nTPM
non-classical monocyte: 24 nTPM
NK-cell: 20 nTPM
T-reg: 19 nTPM
memory B-cell: 19 nTPM

Brain region

cerebral cortex: 25 nTPM
thalamus: 24 nTPM
midbrain: 24 nTPM
choroid plexus: 24 nTPM
cerebellum: 24 nTPM
basal ganglia: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF6.

Disease | AllUniProt

Conditions RNF6 is implicated in, by any mechanism.

Esophageal cancer (ESCR) MIM:133239

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Esophageal squamous cell carcinoma, somatic

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.01
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF6 as an antibody target. Whether an autoantibody or antibody against RNF6 could matter depends on whether native RNF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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