Seroatlas · Human Serome Atlas

RNF214

RING finger protein 214

Also known as: DKFZp547C195, RN214_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8ND24
Gene: RNF214
Ensembl: ENSG00000167257
Chromosome: 11
Canonical length: 703 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin-protein transferase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

703 residues, UniProt reviewed canonical sequence.

>Q8ND24|RNF214
     1  MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL SVSSQTITKE
    61  NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL SGSGSQSDLK DVASTAGEEG
   121  DTSLRESLHP VTRSLKAGCH TKQLASRNCS EEKSPQTSIL KEGNRDTSLD FRPVVSPANG
   181  VEGVRVDQDD DQDSSSLKLS QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY
   241  QEVLDKQRQV ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF
   301  LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK AEILSLESRK
   361  ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR LNGVRIMKKN VRDQFNSHIQ
   421  LVRNGAKLSS LPQIPTPTLP PPPSETDFML QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD
   481  PRSLSFPILN PALSQPSQPS SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV
   541  KASAETPRPQ PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV
   601  AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH APATCKLCLM
   661  CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP TLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF214 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

pancreas: 21 nTPM
testis: 17 nTPM
skeletal muscle: 17 nTPM
thymus: 13 nTPM
thyroid gland: 13 nTPM
tongue: 12 nTPM

Single-cell type

myonuclei: 86 nCPM
undifferentiated spermatogonia: 82 nCPM
early primary spermatocytes: 79 nCPM
late primary spermatocytes: 71 nCPM
differentiating spermatogonia: 56 nCPM
salivary myoepithelial cells: 56 nCPM

Immune cell

T-reg: 21 nTPM
memory CD4 T-cell: 7.8 nTPM
basophil: 6.4 nTPM
memory CD8 T-cell: 4 nTPM
eosinophil: 2.7 nTPM
classical monocyte: 2.5 nTPM

Brain region

white matter: 37 nTPM
cerebellum: 35 nTPM
hypothalamus: 35 nTPM
thalamus: 35 nTPM
medulla oblongata: 34 nTPM
basal ganglia: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.91
gnomAD missense Z: 1.15
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF214 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF214 as an antibody target. Whether an autoantibody or antibody against RNF214 could matter depends on whether native RNF214 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF214 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF214 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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