RNF180

Protein identityUniProt · HPA

UniProt accession

Q86T96

Gene

RNF180

Ensembl

ENSG00000164197

Chromosome

5

Canonical length

592 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in norepinephrine metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and serotonin metabolic process. Predicted to act upstream of or within several processes, including adult behavior; positive regulation of protein ubiquitination; and protein polyubiquitination. Predicted to be located in endoplasmic reticulum; membrane; and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q86T96|RNF180
     1  MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW
    61  HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT
   121  DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE
   181  ALCLEVRPTY FEMKNEKLLS KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT
   241  LLPTLYEIHS KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH
   301  ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE HLSPLDFLHS
   361  ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY SGVGLLDHMT LNNEMSTDED
   421  NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH IFCEPCLRTL AKDNPSSTPC PLCRTIISRV
   481  FFQTELNNAT KTFFTKEYLK IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF
   541  PHGAHRMDYL HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF180 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

24 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.84

gnomAD pLI

0

gnomAD missense Z

0.62

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adult behavior
• norepinephrine metabolic process
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• positive regulation of protein ubiquitination
• protein polyubiquitination
• serotonin metabolic process

Molecular functions

• ubiquitin conjugating enzyme binding
• ubiquitin protein ligase activity
• zinc ion binding

Cellular components

• endoplasmic reticulum membrane
• nuclear envelope

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, RING-type
• Zinc finger, RING/FYVE/PHD-type
• Zinc finger, RING-type, conserved site
• Zinc finger, C3HC4 RING-type
• Zinc finger, C3HC4 type (RING finger)
• E3 ubiquitin-protein ligase RNF180
• E3 ubiquitin-protein ligase RNF180, C-terminal domain
• E3 ubiquitin-protein ligase RNF180 C-terminus

KeywordsUniProt

• Endoplasmic reticulum
• Membrane
• Metal-binding
• Nucleus
• Phosphoprotein
• Transferase
• Transmembrane
• Transmembrane helix
• Ubl conjugation pathway
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of RNF180 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ZIC2