Seroatlas · Human Serome Atlas

RNF175

RING finger protein 175

Also known as: FLJ34190, RN175_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4F7
Gene: RNF175
Ensembl: ENSG00000145428
Chromosome: 4
Canonical length: 328 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q8N4F7|RNF175
     1  MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS MHVEMILIFL
    61  CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL YWWRFLSMWG MFSVITSYIL
   121  FRATRKPLSG RTPRLVYKWF LLIYKLSYAF GVVGYLAIMF TMCGFNLFFK IKARDSMDFG
   181  IVSLFYGLYY GVMGRDFAEI CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE
   241  EGLIENTYQL SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI
   301  LDWLRYLVAW QPVVIGIVQG IIYSLGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF175 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 26 nTPM
basal ganglia: 21 nTPM
hypothalamus: 18 nTPM
cerebellum: 15 nTPM
hippocampal formation: 13 nTPM
amygdala: 13 nTPM

Single-cell type

pituitary stem cells: 367 nCPM
brain inhibitory neurons: 112 nCPM
other brain neurons: 97 nCPM
neutrophils: 87 nCPM
brain excitatory neurons: 86 nCPM
late primary spermatocytes: 65 nCPM

Immune cell

neutrophil: 2.4 nTPM
naive CD4 T-cell: 2.2 nTPM
non-classical monocyte: 2.1 nTPM
classical monocyte: 1.2 nTPM
intermediate monocyte: 0.9 nTPM
myeloid DC: 0.9 nTPM

Brain region

hypothalamus: 27 nTPM
cerebral cortex: 26 nTPM
basal ganglia: 20 nTPM
thalamus: 19 nTPM
pons: 18 nTPM
white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ERAD pathway

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF175 as an antibody target. Whether an autoantibody or antibody against RNF175 could matter depends on whether native RNF175 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF175 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF175 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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