RNASE8
Ribonuclease 8
Also known as: RAE2, RNAS8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TDE3
- Gene
- RNASE8
- Ensembl
- ENSG00000173431
- Chromosome
- 14
- Canonical length
- 154 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014]
Canonical amino-acid sequenceUniProt
154 residues, UniProt reviewed canonical sequence.
>Q8TDE3|RNASE8
1 MAPARAGCCP LLLLLLGLWV AEVLVRAKPK DMTSSQWFKT QHVQPSPQAC NSAMSIINKY
61 TERCKDLNTF LHEPFSSVAI TCQTPNIACK NSCKNCHQSH GPMSLTMGEL TSGKYPNCRY
121 KEKHLNTPYI VACDPPQQGD PGYPLVPVHL DKVVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNASE8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 52 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 52 nTPM
- pancreas: 0.2 nTPM
- skin: 0.2 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- salivary acinar cells: 1.3 nCPM
- early spermatids: 0.1 nCPM
- pericytes: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.5 nTPM
- hypothalamus: 0.5 nTPM
- medulla oblongata: 0.5 nTPM
- pons: 0.5 nTPM
- thalamus: 0.5 nTPM
- hippocampal formation: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.74
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antifungal innate immune response
- defense response to fungus
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
- innate immune response
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNASE8 as an antibody target. Whether an autoantibody or antibody against RNASE8 could matter depends on whether native RNASE8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNASE8 is annotated as secreted, so native RNASE8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label RNASE8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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