Seroatlas · Human Serome Atlas

RNASE7

Ribonuclease 7

Also known as: RAE1, RNAS7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1E1
Gene: RNASE7
Ensembl: ENSG00000165799
Chromosome: 14
Canonical length: 156 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

156 residues, UniProt reviewed canonical sequence.

>Q9H1E1|RNASE7
     1  MAPARAGFCP LLLLLLLGLW VAEIPVSAKP KGMTSSQWFK IQHMQPSPQA CNSAMKNINK
    61  HTKRCKDLNT FLHEPFSSVA ATCQTPKIAC KNGDKNCHQS HGAVSLTMCK LTSGKHPNCR
   121  YKEKRQNKSY VVACKPPQKK DSQQFHLVPV HLDRVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNASE7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

esophagus: 70 nTPM
skin: 26 nTPM
tonsil: 23 nTPM
cervix: 13 nTPM
vagina: 9.4 nTPM
gallbladder: 6.2 nTPM

Single-cell type

esophageal apical cells: 341 nCPM
epididymal basal cells: 44 nCPM
ocular epithelial cells: 38 nCPM
epididymal efferent duct ciliated cells: 22 nCPM
breast myoepithelial cells: 10 nCPM
syncytiotrophoblasts: 8.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
medulla oblongata: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0.12
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNASE7 as an antibody target. Whether an autoantibody or antibody against RNASE7 could matter depends on whether native RNASE7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNASE7 is annotated as secreted, so native RNASE7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RNASE7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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