Seroatlas · Human Serome Atlas

RNASE6

Ribonuclease K6

Also known as: RAD1, RNAS6_HUMAN, RNaseK6, RNS6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q93091
Gene: RNASE6
Ensembl: ENSG00000169413
Chromosome: 14
Canonical length: 150 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>Q93091|RNASE6
     1  MVLCFPLLLL LLVLWGPVCP LHAWPKRLTK AHWFEIQHIQ PSPLQCNRAM SGINNYTQHC
    61  KHQNTFLHDS FQNVAAVCDL LSIVCKNRRH NCHQSSKPVN MTDCRLTSGK YPQCRYSAAA
   121  QYKFFIVACD PPQKSDPPYK LVPVHLDSIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNASE6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

lymph node: 104 nTPM
tonsil: 79 nTPM
epididymis: 74 nTPM
spleen: 65 nTPM
appendix: 56 nTPM
gallbladder: 45 nTPM

Single-cell type

kupffer cells: 594 nCPM
hofbauer cells: 289 nCPM
pdcs: 256 nCPM
monocytes: 241 nCPM
macrophages: 239 nCPM
cdc: 216 nCPM

Immune cell

plasmacytoid DC: 1,242 nTPM
classical monocyte: 539 nTPM
myeloid DC: 514 nTPM
basophil: 443 nTPM
naive B-cell: 412 nTPM
total PBMC: 330 nTPM

Brain region

white matter: 32 nTPM
medulla oblongata: 19 nTPM
thalamus: 19 nTPM
hypothalamus: 14 nTPM
pons: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0.08
gnomAD missense Z: -0.23
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNASE6 as an antibody target. Whether an autoantibody or antibody against RNASE6 could matter depends on whether native RNASE6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNASE6 is annotated as secreted, so native RNASE6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RNASE6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...