RNASE4
Ribonuclease 4
Also known as: RAB1, RNAS4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P34096
- Gene
- RNASE4
- Ensembl
- ENSG00000258818
- Chromosome
- 14
- Canonical length
- 147 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Canonical amino-acid sequenceUniProt
147 residues, UniProt reviewed canonical sequence.
>P34096|RNASE4
1 MALQRTHSLL LLLLLTLLGL GLVQPSYGQD GMYQRFLRQH VHPEETGGSD RYCNLMMQRR
61 KMTLYHCKRF NTFIHEDIWN IRSICSTTNI QCKNGKMNCH EGVVKVTDCR DTGSSRAPNC
121 RYRAIASTRR VVIACEGNPQ VPVHFDGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNASE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 447 nTPM
Expression across tissuesHPA
Tissue
- liver: 447 nTPM
- ovary: 105 nTPM
- adipose tissue: 103 nTPM
- breast: 94 nTPM
- blood vessel: 93 nTPM
- stomach: 80 nTPM
Single-cell type
- gastric chief cells: 122 nCPM
- goblet cells: 104 nCPM
- foveolar cells: 97 nCPM
- epididymal efferent duct absorptive cells: 87 nCPM
- parietal cells: 85 nCPM
- neuroendocrine cells: 73 nCPM
Immune cell
- classical monocyte: 24 nTPM
- myeloid DC: 14 nTPM
- total PBMC: 8.4 nTPM
- memory B-cell: 5.3 nTPM
- naive B-cell: 5 nTPM
- T-reg: 3.4 nTPM
Brain region
- choroid plexus: 11 nTPM
- hypothalamus: 10 nTPM
- white matter: 9.2 nTPM
- medulla oblongata: 7.9 nTPM
- spinal cord: 7.4 nTPM
- midbrain: 7.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNASE4 as an antibody target. Whether an autoantibody or antibody against RNASE4 could matter depends on whether native RNASE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNASE4 is annotated as secreted, so native RNASE4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label RNASE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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