RNASE3
Eosinophil cationic protein
Also known as: ECP, ECP_HUMAN, RAF1, RNS3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P12724
- Gene
- RNASE3
- Ensembl
- ENSG00000169397
- Chromosome
- 14
- Canonical length
- 160 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
Canonical amino-acid sequenceUniProt
160 residues, UniProt reviewed canonical sequence.
>P12724|RNASE3
1 MVPKLFTSQI CLLLLLGLMG VEGSLHARPP QFTRAQWFAI QHISLNPPRC TIAMRAINNY
61 RWRCKNQNTF LRTTFANVVN VCGNQSIRCP HNRTLNNCHR SRFRVPLLHC DLINPGAQNI
121 SNCTYADRPG RRFYVVACDN RDPRDSPRYP VVPVHLDTTILocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNASE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 856 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 856 nTPM
- spleen: 9 nTPM
- thymus: 8.6 nTPM
- retina: 3.5 nTPM
- lung: 2.5 nTPM
- liver: 1.8 nTPM
Single-cell type
- neutrophil progenitors: 284 nCPM
- monocyte progenitors: 99 nCPM
- early spermatids: 20 nCPM
- late primary spermatocytes: 12 nCPM
- late spermatids: 12 nCPM
- monocytes: 6.7 nCPM
Immune cell
- eosinophil: 307 nTPM
- myeloid DC: 16 nTPM
- basophil: 14 nTPM
- classical monocyte: 9.6 nTPM
- total PBMC: 4.6 nTPM
- neutrophil: 4.3 nTPM
Brain region
- white matter: 2.1 nTPM
- medulla oblongata: 1.7 nTPM
- hypothalamus: 1.5 nTPM
- spinal cord: 1.5 nTPM
- cerebral cortex: 1.4 nTPM
- pons: 1.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.42
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antibacterial humoral response
- antimicrobial humoral immune response mediated by antimicrobial peptide
- chemotaxis
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
- induction of bacterial agglutination
- innate immune response
- innate immune response in mucosa
- RNA catabolic process
Molecular functions
- endonuclease activity
- hydrolase activity
- lipopolysaccharide binding
- nucleic acid binding
- RNA nuclease activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNASE3 as an antibody target. Whether an autoantibody or antibody against RNASE3 could matter depends on whether native RNASE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNASE3 is annotated as secreted, so native RNASE3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label RNASE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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