RNASE2
Non-secretory ribonuclease
Also known as: EDN, RAF3, RNAS2_HUMAN, RNS2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P10153
- Gene
- RNASE2
- Ensembl
- ENSG00000169385
- Chromosome
- 14
- Canonical length
- 161 aa
- Protein class
- Enzymes, Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]
Canonical amino-acid sequenceUniProt
161 residues, UniProt reviewed canonical sequence.
>P10153|RNASE2
1 MVPKLFTSQI CLLLLLGLLA VEGSLHVKPP QFTWAQWFET QHINMTSQQC TNAMQVINNY
61 QRRCKNQNTF LLTTFANVVN VCGNPNMTCP SNKTRKNCHH SGSQVPLIHC NLTTPSPQNI
121 SNCRYAQTPA NMFYIVACDN RDQRRDPPQY PVVPVHLDRI ILocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNASE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 1,615 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 1,615 nTPM
- spleen: 34 nTPM
- thymus: 14 nTPM
- lung: 12 nTPM
- smooth muscle: 9 nTPM
- choroid plexus: 8.9 nTPM
Single-cell type
- monocyte progenitors: 1,013 nCPM
- neutrophil progenitors: 592 nCPM
- monocytes: 268 nCPM
- macrophages: 47 nCPM
- kupffer cells: 30 nCPM
- platelets: 14 nCPM
Immune cell
- eosinophil: 1,355 nTPM
- basophil: 459 nTPM
- myeloid DC: 192 nTPM
- classical monocyte: 109 nTPM
- total PBMC: 40 nTPM
- intermediate monocyte: 19 nTPM
Brain region
- white matter: 8.7 nTPM
- medulla oblongata: 7.3 nTPM
- choroid plexus: 5.2 nTPM
- pons: 5.2 nTPM
- spinal cord: 5.2 nTPM
- thalamus: 5.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.38
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNASE2 as an antibody target. Whether an autoantibody or antibody against RNASE2 could matter depends on whether native RNASE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNASE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RNASE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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