Seroatlas · Human Serome Atlas

RIPOR3

RIPOR family member 3

Also known as: C20orf175, C20orf176, dJ530I15.2, dJ530I15.3, FAM65C, RIPR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MK2
Gene: RIPOR3
Ensembl: ENSG00000042062
Chromosome: 20
Canonical length: 946 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for RIPOR3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

946 residues, UniProt reviewed canonical sequence.

>Q96MK2|RIPOR3
     1  MSVRLRFLSP GDTGAVGVVG RSASFAGFSS AQSRRIAKSI NRNSVRSRMP AKSSKMYGTL
    61  RKGSVCADPK PQQVKKIFEA LKRGLKEYLC VQQAELDHLS GRHKDTRRNS RLAFYYDLDK
   121  QTRCVERHIR KMEFHISKVD ELYEDYCIQC RLRDGASSMQ RAFARCPPSR AARESLQELG
   181  RSLHECAEDM WLIEGALEVH LGEFHIRMKG LVGYARLCPG DHYEVLMRLG RQRWKLKGRI
   241  ESDDSQTWDE EEKAFIPTLH ENLDIKVTEL RGLGSLAVGA VTCDIADFFT TRPQVIVVDI
   301  TELGTIKLQL EVQWNPFDTE SFLVSPSPTG KFSMGSRKGS LYNWTPPSTP SFRERYYLSV
   361  LQQPTQQALL LGGPRATSIL SYLSDSDLRG PSLRSQSQEL PEMDSFSSED PRDTETSTSA
   421  STSDVGFLPL TFGPHASIEE EAREDPLPPG LLPEMAHLSG GPFAEQPGWR NLGGESPSLP
   481  QGSLFHSGTA SSSQNGHEEG ATGDREDGPG VALEGPLQEV LELLRPTDST QPQLRELEYQ
   541  VLGFRDRLKP CRARQEHTSA ESLMECILES FAFLNADFAL DELSLFGGSQ GLRKDRPLPP
   601  PSSLKASSRE LTAGAPELDV LLMVHLQVCK ALLQKLASPN LSRLVQECLL EEVAQQKHVL
   661  ETLSVLDFEK VGKATSIEEI IPQASRTKGC LKLWRGCTGP GRVLSCPATT LLNQLKKTFQ
   721  HRVRGKYPGQ LEIACRRLLE QVVSCGGLLP GAGLPEEQII TWFQFHSYLQ RQSVSDLEKH
   781  FTQLTKEVTL IEELHCAGQA KVVRKLQGKR LGQLQPLPQT LRAWALLQLD GTPRVCRAAS
   841  ARLAGAVRNR SFREKALLFY TNALAENDAR LQQAACLALK HLKGIESIDQ TASLCQSDLE
   901  AVRAAARETT LSFGEKGRLA FEKMDKLCSE QREVFCQEAD VEITIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPOR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

kidney: 40 nTPM
cervix: 34 nTPM
fallopian tube: 32 nTPM
endometrium: 21 nTPM
bone marrow: 21 nTPM
adipose tissue: 18 nTPM

Single-cell type

epicardial cells: 252 nCPM
platelets: 224 nCPM
loop of henle epithelial cells: 213 nCPM
pericytes: 143 nCPM
fibro-adipogenic progenitors: 142 nCPM
megakaryocyte-erythroid progenitors: 128 nCPM

Immune cell

eosinophil: 0.3 nTPM
basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 8.1 nTPM
basal ganglia: 3.3 nTPM
medulla oblongata: 3.2 nTPM
cerebral cortex: 3 nTPM
midbrain: 3 nTPM
pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of RIPOR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RHOA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPOR3 as an antibody target. Whether an autoantibody or antibody against RIPOR3 could matter depends on whether native RIPOR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPOR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIPOR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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