Seroatlas · Human Serome Atlas

RHCG

Ammonium transporter Rh type C

Also known as: C15orf6, PDRC2, RHCG_HUMAN, RHGK, SLC42A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBD6
Gene
RHCG
Ensembl
ENSG00000140519
Chromosome
15
Canonical length
479 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homotrimer

OverviewNCBI Gene

Enables several functions, including ammonium channel activity; ankyrin binding activity; and carbon dioxide transmembrane transporter activity. Involved in ammonium transmembrane transport; intracellular monoatomic ion homeostasis; and transepithelial ammonium transport. Located in apical plasma membrane and basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q9UBD6|RHCG
     1  MAWNTNLRWR LPLTCLLLQV IMVILFGVFV RYDFEADAHW WSERTHKNLS DMENEFYYRY
    61  PSFQDVHVMV FVGFGFLMTF LQRYGFSAVG FNFLLAAFGI QWALLMQGWF HFLQDRYIVV
   121  GVENLINADF CVASVCVAFG AVLGKVSPIQ LLIMTFFQVT LFAVNEFILL NLLKVKDAGG
   181  SMTIHTFGAY FGLTVTRILY RRNLEQSKER QNSVYQSDLF AMIGTLFLWM YWPSFNSAIS
   241  YHGDSQHRAA INTYCSLAAC VLTSVAISSA LHKKGKLDMV HIQNATLAGG VAVGTAAEMM
   301  LMPYGALIIG FVCGIISTLG FVYLTPFLES RLHIQDTCGI NNLHGIPGII GGIVGAVTAA
   361  SASLEVYGKE GLVHSFDFQG FNGDWTARTQ GKFQIYGLLV TLAMALMGGI IVGLILRLPF
   421  WGQPSDENCF EDAVYWEMPE GNSTVYIPED PTFKPSGPSV PSVPMVSPLP MASSVPLVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHCG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
3,828 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 3,828 nTPM
  • vagina: 1,650 nTPM
  • cervix: 1,080 nTPM
  • salivary gland: 506 nTPM
  • tonsil: 433 nTPM
  • kidney: 115 nTPM

Single-cell type

  • esophageal apical cells: 45,475 nCPM
  • esophageal suprabasal cells: 13,017 nCPM
  • suprabasal keratinocytes: 3,207 nCPM
  • esophageal basal cells: 2,188 nCPM
  • submucosal glandular cells: 528 nCPM
  • renal collecting duct intercalated cells: 351 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 4.2 nTPM
  • basal ganglia: 3.4 nTPM
  • white matter: 3.1 nTPM
  • spinal cord: 2.9 nTPM
  • thalamus: 2.8 nTPM
  • hippocampal formation: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
0.29
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHCG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHCG as an antibody target. Whether an autoantibody or antibody against RHCG could matter depends on whether native RHCG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHCG is annotated at the cell surface, where native RHCG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHCG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RHCG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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