Seroatlas · Human Serome Atlas

RCN2

Reticulocalbin-2

Also known as: E6BP, ERC-55, ERC55, RCN2_HUMAN, TCBP49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14257
Gene
RCN2
Ensembl
ENSG00000117906
Chromosome
15
Canonical length
317 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q14257|RCN2
     1  MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED VDEYVKLGHE
    61  EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ EAKQQFVEYD KNSDDTVTWD
   121  EYNIQMYDRV IDFDENTALD DAEEESFRKL HLKDKKRFEK ANQDSGPGLS LEEFIAFEHP
   181  EEVDYMTEFV IQEALEEHDK NGDGFVSLEE FLGDYRWDPT ANEDPEWILV EKDRFVNDYD
   241  KDNDGRLDPQ ELLPWVVPNN QGIAQEEALH LIDEMDLNGD KKLSEEEILE NPDLFLTSEA
   301  TDYGRQLHDD YFYHDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
304 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 304 nTPM
  • testis: 87 nTPM
  • parathyroid gland: 76 nTPM
  • hypothalamus: 64 nTPM
  • tongue: 56 nTPM
  • cerebral cortex: 56 nTPM

Single-cell type

  • epididymal principal cells: 822 nCPM
  • early primary spermatocytes: 467 nCPM
  • late primary spermatocytes: 428 nCPM
  • extravillous trophoblasts: 377 nCPM
  • epididymal basal cells: 219 nCPM
  • epididymal efferent duct absorptive cells: 218 nCPM

Immune cell

  • memory CD8 T-cell: 28 nTPM
  • naive CD4 T-cell: 26 nTPM
  • naive CD8 T-cell: 25 nTPM
  • MAIT T-cell: 25 nTPM
  • memory B-cell: 24 nTPM
  • NK-cell: 24 nTPM

Brain region

  • hypothalamus: 76 nTPM
  • pons: 59 nTPM
  • midbrain: 55 nTPM
  • thalamus: 54 nTPM
  • cerebral cortex: 51 nTPM
  • basal ganglia: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0.03
gnomAD missense Z
0.84
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCN2 as an antibody target. Whether an autoantibody or antibody against RCN2 could matter depends on whether native RCN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...