Seroatlas · Human Serome Atlas

RASSF9

Ras association domain-containing protein 9

Also known as: P-CIP1, PAMCI, RASF9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75901
Gene
RASSF9
Ensembl
ENSG00000198774
Chromosome
12
Canonical length
435 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene localizes to perinuclear endosomes. This protein associates with peptidylglycine alpha-amidating monooxygenase, and may be involved with the trafficking of this enzyme through secretory or endosomal pathways. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>O75901|RASSF9
     1  MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA DVIQALLEEH
    61  EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW KAWGDEQPNM QFVLVKADAF
   121  LPVPLWRTAE AKLVQNTEKL WELSPANYMK TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR
   181  DNMETLVHLI ISQDHTIHQQ VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF
   241  SEVEQNLDLQ YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE
   301  DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL QMKAKEYELL
   361  AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR VFSNYTNDTD SDTGISSNHS
   421  QDSETTVGDV VLLST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
6 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 6 nTPM
  • esophagus: 5.3 nTPM
  • lung: 5.3 nTPM
  • heart muscle: 4.2 nTPM
  • thyroid gland: 4.1 nTPM
  • endometrium: 3.2 nTPM

Single-cell type

  • ependymal cells: 286 nCPM
  • lymphatic endothelial cells: 106 nCPM
  • fallopian secretory cells: 105 nCPM
  • respiratory secretory cells: 102 nCPM
  • pancreatic duct cells: 91 nCPM
  • transitional alveolar cells: 80 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 25 nTPM
  • spinal cord: 15 nTPM
  • midbrain: 12 nTPM
  • white matter: 9 nTPM
  • hypothalamus: 6.2 nTPM
  • thalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASSF9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASSF9 as an antibody target. Whether an autoantibody or antibody against RASSF9 could matter depends on whether native RASSF9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASSF9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASSF9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RASSF9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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