Seroatlas · Human Serome Atlas

RAD51AP2

RAD51-associated protein 2

Also known as: FLJ17540, R51A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q09MP3
Gene: RAD51AP2
Ensembl: ENSG00000214842
Chromosome: 2
Canonical length: 1159 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitotic chromosome,Cytosol

OverviewNCBI Gene

Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1159 residues, UniProt reviewed canonical sequence.

>Q09MP3|RAD51AP2
     1  MSLPQPTPRM AELRKPTSSL TPPEDPDSQP PSSKRLCLEE PGGVFKAGWR LPLVPRLSEA
    61  EKVWELSPRP FKGLLVSTNA IFDNSTDSCV EKSVSGKQIC NLKCSNLKFQ MSSCLQSPPS
   121  QSPDSDLRAS GRSEAGLHDR EAFSVHRSNS SKAGVSQLLP STSIHDIHGI RNENRKQQFV
   181  QGRDNVHKEN PFLDVTFYKE TKSPFHEIKN RCKANSVVPS NKRENNISSS VLKISKSQNQ
   241  PSLEIAKPSY FRDSGTISVP QFPMDLNSKM SSVYLKEIAK KKNDKKEAYV RDFTNIYWSQ
   301  NRPDVKKQKL QNDKKTVEAE NIFSKCYEND YPSLSSQNTC KRKDLISSNY CNCSSIQCNV
   361  RDSRKNFAIL ENANWEEAEC LDSYVLTRLE KSQNWDCNVR HILRRNRGNC WIINNCKTKC
   421  ENMKKTEEKW NWLLLLEIDL LSKEDYHCAK VINAYEEQSK LLVREILGSQ TALITTVWLN
   481  GKGENDNTLQ LRYNTTQKVF HVNNPFESFI IEIFYFHKSI SGNKKDNSIL TCCNILKCKK
   541  QIGIIGIQNL ITRNMNTNIK NGILSIYLQD SVSEPLDILL KTNIAFLLNN FDSLTRIEND
   601  FELEEECIFK CMLYLKYPKN IVENHTAYLV KILTSSRLLE DNMKPMLKKR KLFRTEQVFE
   661  KSKKKLINSF SMTTQNTGFP IFETYEKIPL LMDFDDMDEI SLIREITCQN MSCPQQVVNV
   721  ENWAHYNSST VKAHGNSCPQ FIQNNRGYIN ENFYEVNMHS QDLNMERKQG HNKISNFDCE
   781  HIFEDLCNVR QQAIPASHNI IHNEETHTTS ITQVLNFWNL LSEIEEKKYD LILKEEVKVT
   841  AESLTNSCQV HKDTKIEKEE KDSFFPMDDM FSVQSVSLIS KEVNVEENKY VNQNYVTNTN
   901  EYESILPERE IANSKDFHRK NDSALYINHQ FETGLSEGND ECFQDLAAKY LSTEALTIVK
   961  DFEMKRKFDL VLEELRMFHE ISRENELLST VETNNGQENY FGENDAEKVK MEIEKDLKMV
  1021  VVNKIRASSS FHDTIAGPNM GKSHQSLFKW KTVPNNGEQE VPNESCYPSR SEEELLYSTS
  1081  EKDCETPLPK RPAFLPDECK EEFNYLLRGG SHFPHGISRV RPLKTCSRPI RIGLSRKARI
  1141  KQLHPYLKQM CYGNLKENF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD51AP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

testis: 8.8 nTPM
cerebral cortex: 0.3 nTPM
cerebellum: 0.2 nTPM
esophagus: 0.2 nTPM
heart muscle: 0.2 nTPM
pancreas: 0.2 nTPM

Single-cell type

early primary spermatocytes: 511 nCPM
ependymal cells: 13 nCPM
late primary spermatocytes: 11 nCPM
early spermatids: 5.4 nCPM
breast lactating cells: 4.7 nCPM
colonocytes: 4.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.8 nTPM
basal ganglia: 1.1 nTPM
white matter: 0.9 nTPM
midbrain: 0.8 nTPM
medulla oblongata: 0.6 nTPM
amygdala: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAD51AP2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 189 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 88

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

protein-containing complex

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of RAD51AP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAD51

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD51AP2 as an antibody target. Whether an autoantibody or antibody against RAD51AP2 could matter depends on whether native RAD51AP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD51AP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD51AP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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