Seroatlas · Human Serome Atlas

R3HCC1L

Coiled-coil domain-containing protein R3HCC1L

Also known as: C10orf28, GIDRP86, PSORT, R3HCL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5L2
Gene: R3HCC1L
Ensembl: ENSG00000166024
Chromosome: 10
Canonical length: 792 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Located in exon-exon junction complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

792 residues, UniProt reviewed canonical sequence.

>Q7Z5L2|R3HCC1L
     1  MQQESERCRV RARRPDMALY VPKARRGAVL LKTGDEEESC GSPNSVVKEK QKESSLSQKE
    61  VFKDKPEARR LNINPDRKEH NCREEKKSST KLRMDTCLQK TNRVCSKRGT TESKEVLSQG
   121  QQQGAPNAGV ITNAPLQRHF KPKKVECLEV ETTDVTGHER ILLSQACLEI SEAQVPSKPF
   181  QNVEFCDFSR HEPDGEAFED KDLEGRIETD TKVLEILYEF PRVFSSVMKP ENMIVPIKLS
   241  SDSEIVQQSM QTSDGILNPS SGGITTTSVP GSPDGVFDQT CVDFEVESVG GIANSTGFIL
   301  DQKDTDSIPA TMGHISLSES TNDTVSPVMI RECEKNDSTA DELHVKHEPP DTAVLAHETH
   361  RDSGFKNVGD ITNKACMMDT TGMSCSDHVT VDSPYVVAVR IADETSINTR SFSKFVGMSA
   421  DATPLHVARS GNDTEDFSNP SACSDIYGES ISSHFTESTG KLIESLSDCA SSLPIKKIAG
   481  SNYNTFLDSE LSMLNGTKVL SDSAVGIDLG STGDTTEALH ELRTAEEFKT EEQDDSGSIE
   541  FGVSFPDRES SSMETSIEPK ATETSHTEGI TAIEESWESM FNDDGDCLDP RLLQEGILMH
   601  IKPENHCSKL SGNTKSRESI QEPRSDYYNH EVPDIDLSDC EFPHVIEIYD FPQEFHTEDL
   661  LRVFCSYQKK GFDIKWVDDT HALGVFSSPI TARDALGIKH TMVKIRPLSQ ATRAAKAKAR
   721  AYAEFLQPAK ERPETSAALA RRLVISALGV RSKQSKTERE AELKKLQEAR ERKRLEAKQR
   781  EDIWEGRDQS TV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against R3HCC1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
bone marrow: 16 nTPM
spleen: 15 nTPM
skin: 15 nTPM
cervix: 14 nTPM
liver: 13 nTPM

Single-cell type

neutrophil progenitors: 173 nCPM
neutrophils: 156 nCPM
sertoli cells: 156 nCPM
microglia: 127 nCPM
melanocytes: 122 nCPM
somatotrophs: 117 nCPM

Immune cell

eosinophil: 18 nTPM
non-classical monocyte: 14 nTPM
T-reg: 14 nTPM
basophil: 12 nTPM
NK-cell: 11 nTPM
memory B-cell: 9.3 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 13 nTPM
basal ganglia: 11 nTPM
medulla oblongata: 10 nTPM
thalamus: 10 nTPM
pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -0.74
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads R3HCC1L as an antibody target. Whether an autoantibody or antibody against R3HCC1L could matter depends on whether native R3HCC1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

R3HCC1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label R3HCC1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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