Seroatlas · Human Serome Atlas

R3HCC1

R3H and coiled-coil domain-containing protein 1

Also known as: DKFZp564N123, R3HC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3T6
Gene: R3HCC1
Ensembl: ENSG00000104679
Chromosome: 8
Canonical length: 440 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q9Y3T6|R3HCC1
     1  MALLCLDGVF LSSAENDFVH RIQEELDRFL LQKQLSKVLL FPPLSSRLRY LIHRTAENFD
    61  LLSSFSVGEG WKRRTVICHQ DIRVPSSDGL SGPCRAPASC PSRYHGPRPI SNQGAAAVPR
   121  GARAGRWYRG RKPDQPLYVP RVLRRQEEWG LTSTSVLKRE APAGRDPEEP GDVGAGDPNS
   181  DQGLPVLMTQ GTEDLKGPGQ RCENEPLLDP VGPEPLGPES QSGKGDMVEM ATRFGSTLQL
   241  DLEKGKESLL EKRLVAEEEE DEEEVEEDGP SSCSEDDYSE LLQEITDNLT KKEIQIEKIH
   301  LDTSSFVEEL PGEKDLAHVV EIYDFEPALK TEDLLATFSE FQEKGFRIQW VDDTHALGIF
   361  PCLASAAEAL TREFSVLKIR PLTQGTKQSK LKALQRPKLL RLVKERPQTN ATVARRLVAR
   421  ALGLQHKKKE RPAVRGPLPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against R3HCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 74 nTPM
retina: 58 nTPM
midbrain: 51 nTPM
skeletal muscle: 51 nTPM
pancreas: 46 nTPM
hippocampal formation: 37 nTPM

Single-cell type

late spermatids: 178 nCPM
late primary spermatocytes: 74 nCPM
rod photoreceptor cells: 69 nCPM
undifferentiated spermatogonia: 64 nCPM
breast myoepithelial cells: 59 nCPM
decidual stromal cells: 50 nCPM

Immune cell

eosinophil: 83 nTPM
gdT-cell: 65 nTPM
T-reg: 62 nTPM
NK-cell: 60 nTPM
memory B-cell: 57 nTPM
myeloid DC: 57 nTPM

Brain region

white matter: 100 nTPM
medulla oblongata: 83 nTPM
pons: 74 nTPM
cerebellum: 63 nTPM
basal ganglia: 59 nTPM
midbrain: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

nucleic acid binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads R3HCC1 as an antibody target. Whether an autoantibody or antibody against R3HCC1 could matter depends on whether native R3HCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

R3HCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label R3HCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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