Seroatlas · Human Serome Atlas

QSOX2

Sulfhydryl oxidase 2

Also known as: DKFZp762A2013, QSCN6L1, QSOX2_HUMAN, SOXN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZRP7
Gene
QSOX2
Ensembl
ENSG00000165661
Chromosome
9
Canonical length
698 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus
Secretome location
Intracellular and membrane

OverviewNCBI Gene

QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

698 residues, UniProt reviewed canonical sequence.

>Q6ZRP7|QSOX2
     1  MAAAGAAVAR SPGIGAGPAL RARRSPPPRA ARLPRLLVLL AAAAVGPGAG GAARLYRAGE
    61  DAVWVLDSGS VRGATANSSA AWLVQFYSSW CGHCIGYAPT WRALAGDVRD WASAIRVAAL
   121  DCMEEKNQAV CHDYDIHFYP TFRYFKAFTK EFTTGENFKG PDRELRTVRQ TMIDFLQNHT
   181  EGSRPPACPR LDPIQPSDVL SLLDNRGSHY VAIVFESNSS YLGREVILDL IPYESIVVTR
   241  ALDGDKAFLE KLGVSSVPSC YLIYPNGSHG LINVVKPLRA FFSSYLKSLP DVRKKSLPLP
   301  EKPHKEENSE IVVWREFDKS KLYTVDLESG LHYLLRVELA AHKSLAGAEL KTLKDFVTVL
   361  AKLFPGRPPV KKLLEMLQEW LASLPLDRIP YNAVLDLVNN KMRISGIFLT NHIKWVGCQG
   421  SRSELRGYPC SLWKLFHTLT VEASTHPDAL VGTGFEDDPQ AVLQTMRRYV HTFFGCKECG
   481  EHFEEMAKES MDSVKTPDQA ILWLWKKHNM VNGRLAGHLS EDPRFPKLQW PTPDLCPACH
   541  EEIKGLASWD EGHVLTFLKQ HYGRDNLLDT YSADQGDSSE GGTLARGEEE EKRLTPPEVS
   601  HGDRDTQSVR PPGALGPRPA LPESLHHSLD GKLQSLDGPG AHKEVGGAAP FLGVDFSSLD
   661  MSLCVVLYVA SSLFLMVMYF FFRVRSRRWK VKHHHPAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QSOX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 31 nTPM
  • cerebellum: 31 nTPM
  • pancreas: 18 nTPM
  • spleen: 15 nTPM
  • thyroid gland: 11 nTPM
  • small intestine: 11 nTPM

Single-cell type

  • lactotrophs: 121 nCPM
  • somatotrophs: 95 nCPM
  • thyrotrophs: 91 nCPM
  • gonadotrophs: 54 nCPM
  • pancreatic islet cells: 40 nCPM
  • b-cells: 36 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • eosinophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 20 nTPM
  • cerebral cortex: 13 nTPM
  • hypothalamus: 13 nTPM
  • medulla oblongata: 12 nTPM
  • midbrain: 12 nTPM
  • basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
0.64
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QSOX2 as an antibody target. Whether an autoantibody or antibody against QSOX2 could matter depends on whether native QSOX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QSOX2 is annotated at the cell surface, where native QSOX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label QSOX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/QSOX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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