Seroatlas · Human Serome Atlas

QSOX1

Sulfhydryl oxidase 1

Also known as: QSCN6, QSOX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00391
Gene
QSOX1
Ensembl
ENSG00000116260
Chromosome
1
Canonical length
747 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>O00391|QSOX1
     1  MRRCNSGSGP PPSLLLLLLW LLAVPGANAA PRSALYSPSD PLTLLQADTV RGAVLGSRSA
    61  WAVEFFASWC GHCIAFAPTW KALAEDVKAW RPALYLAALD CAEETNSAVC RDFNIPGFPT
   121  VRFFKAFTKN GSGAVFPVAG ADVQTLRERL IDALESHHDT WPPACPPLEP AKLEEIDGFF
   181  ARNNEEYLAL IFEKGGSYLG REVALDLSQH KGVAVRRVLN TEANVVRKFG VTDFPSCYLL
   241  FRNGSVSRVP VLMESRSFYT AYLQRLSGLT REAAQTTVAP TTANKIAPTV WKLADRSKIY
   301  MADLESALHY ILRIEVGRFP VLEGQRLVAL KKFVAVLAKY FPGRPLVQNF LHSVNEWLKR
   361  QKRNKIPYSF FKTALDDRKE GAVLAKKVNW IGCQGSEPHF RGFPCSLWVL FHFLTVQAAR
   421  QNVDHSQEAA KAKEVLPAIR GYVHYFFGCR DCASHFEQMA AASMHRVGSP NAAVLWLWSS
   481  HNRVNARLAG APSEDPQFPK VQWPPRELCS ACHNERLDVP VWDVEATLNF LKAHFSPSNI
   541  ILDFPAAGSA ARRDVQNVAA APELAMGALE LESRNSTLDP GKPEMMKSPT NTTPHVPAEG
   601  PEASRPPKLH PGLRAAPGQE PPEHMAELQR NEQEQPLGQW HLSKRDTGAA LLAESRAEKN
   661  RLWGPLEVRR VGRSSKQLVD IPEGQLEARA GRGRGQWLQV LGGGFSYLDI SLCVGLYSLS
   721  FMGLLAMYTY FQAKIRALKG HAGHPAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QSOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
236 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 236 nTPM
  • lung: 195 nTPM
  • ovary: 188 nTPM
  • esophagus: 176 nTPM
  • stomach: 171 nTPM
  • testis: 169 nTPM

Single-cell type

  • extravillous trophoblasts: 2,747 nCPM
  • esophageal apical cells: 956 nCPM
  • hepatic stellate cells: 575 nCPM
  • neutrophils: 273 nCPM
  • foveolar cells: 265 nCPM
  • goblet cells: 257 nCPM

Immune cell

  • classical monocyte: 53 nTPM
  • neutrophil: 40 nTPM
  • myeloid DC: 39 nTPM
  • intermediate monocyte: 30 nTPM
  • non-classical monocyte: 29 nTPM
  • total PBMC: 29 nTPM

Brain region

  • white matter: 81 nTPM
  • medulla oblongata: 65 nTPM
  • spinal cord: 53 nTPM
  • pons: 51 nTPM
  • hypothalamus: 50 nTPM
  • thalamus: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
-0.1
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QSOX1 as an antibody target. Whether an autoantibody or antibody against QSOX1 could matter depends on whether native QSOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QSOX1 is annotated as secreted, so native QSOX1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label QSOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/QSOX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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